EXPRESSION OF GRANULOCYTE-COLONY-STIMULATING FACTOR-RECEPTOR ON CD10-POSITIVE HUMAN B-CELL PRECURSORS

被引：12

作者：

INUKAI, T ^{[1
]}

SUGITA, K ^{[1
]}

IIJIMA, K ^{[1
]}

TEZUKA, T ^{[1
]}

GOI, K ^{[1
]}

KOJIKA, S ^{[1
]}

SHIRAISHI, K ^{[1
]}

KAGAMI, K ^{[1
]}

NAKAZAWA, S ^{[1
]}

机构：

[1] YAMANASHI MED UNIV, DEPT PAEDIAT, YAMANASHI 40938, JAPAN

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1995年 / 89卷 / 03期

关键词：

CD10; G-CSF RECEPTOR; B-CELL PRECURSOR; ALL IN REMISSION;

D O I：

10.1111/j.1365-2141.1995.tb08373.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We examined the expression of CD10 and G-CSF receptor (G-CSFR) on the lymphoid population of mononuclear cells obtained from bone marrow (BM) using two-colour analysis. In the BM of children with ALL in G-CSF remission, the CD10(+) population was significantly increased (20.6 +/- 5.1% compared with that of controls (2.5 +/-.0.5%). More than half (61.3 +/- 2.9%) of the CD10(+) cells co-expressed G-CSFR, but not CD13. These results indicate G-CSFR(+) B-cell precursors are markedly increased in BM of ALL in remission, suggesting the probable involvement of G-CSF in the human early B-cell ontogeny.

引用

页码：623 / 626

页数：4

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