SIMULTANEOUS MEASUREMENTS OF PIAL ARTERIOLAR DIAMETER AND LASER-DOPPLER FLOW DURING SOMATOSENSORY STIMULATION

被引：70

作者：

NGAI, AC ^{[1
]}

MENO, JR ^{[1
]}

WINN, HR ^{[1
]}

机构：

[1] UNIV WASHINGTON, HARBORVIEW MED CTR, SCH MED, DEPT NEUROL SURG, SEATTLE, WA 98104 USA

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 1995年 / 15卷 / 01期

关键词：

CRANIAL WINDOW; LASER-DOPPLER FLOWMETRY; PIAL CIRCULATION; SCIATIC NERVE; SOMATOSENSORY CORTEX;

D O I：

10.1038/jcbfm.1995.14

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We simultaneously measured pial arteriolar diameter and changes in cortical blood flow during activation of the somatosensory cortex by sciatic nerve stimulation. The pial vasculature was visualized with a closed-cranial window technique in chloralose-anesthetized rats (n = 13). Local blood flow was monitored with laser-Doppler flowmetry. During stimulation of the sciatic nerve (0.2 V, 5 Hz, 20 s), vascular diameter and laser-Doppler flow consistently displayed similar response profiles. With 0.5-ms stimulation pulses, the responses showed an initial peak followed by a smaller but sustained plateau dilation. In contrast, 5-ms pulses evoked a monotonically rising response. Our results support the concept that pial arteriolar diameter changes reflect cortical blood flow responses during somatosensory stimulation.

引用

页码：124 / 127

页数：4

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