INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-1 LEVELS IN DIABETIC ADOLESCENTS AND THEIR RELATIONSHIP TO METABOLIC CONTROL

被引：42

作者：

HOLLY, JMP

DUNGER, DB

EDGE, JA

SMITH, CP

CHARD, T

WASS, JAH

机构：

[1] Departments of Chemical Endocrinology, Reproductive Physiology and Endocrinology, Centre for Clinical Research, St. Bartholomew's Hospital, London

[2] Department of Paediatrics, The John Radcliffe Hospital, Oxford

来源：

DIABETIC MEDICINE | 1990年 / 7卷 / 07期

关键词：

Diabetes mellitus; Insulin‐like growth factor binding protein‐1; Insulin‐like growth factor‐I; Metabolic control;

D O I：

10.1111/j.1464-5491.1990.tb01460.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Circulating levels of the low molecular weight insulin‐like growth factor binding protein‐1 (IGFBP‐1) are insulin dependent and vary markedly throughout the day. IGFBP‐1 levels are abnormally high in diabetes but the relationship between this and the metabolic status of the patient has not been defined. We have therefore measured fasting IGFBP‐1 levels at 0800 h in 32 diabetic adolescents. IGFBP‐1 was measured in 19 of these patients after a normal night and in 27 after a night of euglycaemia, maintained with a glucose clamp. In 13 patients both studies were performed and could be compared. Puberty‐matched control data were obtained from 69 normal children. In normal prepubertal children IGFBP‐1 levels were high; lower levels were found with advancing pubertal development. This fall in IGFBP‐1 correlated with pubertal stage (r = 0.68, p < 0.001) and with fasting insulin levels (r = 0.60, p < 0.001) which rose with pubertal advancement. In the diabetic children IGFBP‐1 levels also correlated inversely with the 0800 h free insulin level but there was no clear relationship with pubertal development. However, when measured after overnight euglycaemia IGFBP‐1 levels correlated inversely with pubertal development (r = 0.67, p < 0.001) as in the normal children. In the patients studied on two comparable occasions the IGFBP‐1 level measured after a normal night relative to that measured under standardized euglycaemic conditions was found to correlate closely with the glycosylated haemoglobin level (r = 0.71, p < 0.005). 1990 Diabetes UK

引用

页码：618 / 623

页数：6

共 23 条

[1]

Holly JMP, Amiel SA, Sandhu RR, Rees LH, Wass JAH., The role of growth hormone in diabetes mellitus, J. Endocrinol, 118, pp. 353-364, (1988)

[2]

Taylor AM, Dunger DB, Grant DB, Preece MA., Somatomedin‐C/IGF‐1 measurement by radioimmunoassay and somatomedin bioactivity in adolescents with insulin dependent diabetes compared with puberty matched controls, Diabetes Res, 9, pp. 177-181, (1988)

[3]

Ballard J., Baxter R., Binoux M., Et al., On the nomenclature of the IGF binding proteins, Acta Endocrinol, 121, pp. 751-752, (1989)

[4]

Baxter RC, Martin JL., Radioimmunoassay of growth hormone‐dependent insulinlike growth factor binding protein in human plasma, J Clin Invest, 78, pp. 1504-1512, (1986)

[5]

Brismar K., Gutniak M., Povoa G., Werner S., Hall K., Insulin regulates the 35 kDa IGF binding protein in patients with diabetes mellitus, J Endocrinol Invest, 11, pp. 599-602, (1988)

[6]

Holly JMP, Biddlecombe RA, Dunger DB, Et al., Circadian variation of GH‐independent IGF‐binding protein in diabetes mellitus and its relationship to insulin. A new role for insulin?, Clin Endocrinol, 29, pp. 667-675, (1988)

[7]

Suikkari A-M, Koivisto VA, Rutanen E-M, Yki-Jarvinen H., Karonen S-L, Seppala M., Insulin regulates the serum levels of low molecular weight insulin‐like growth factorbinding protein, J Clin Endocrinol Metab, 66, pp. 266-272, (1988)

[8]

Drop SLS, Valiquette G., Guyda HJ, Corvol MT, Posner BI., Partial purification and characterization of a binding protein for insulin‐like activity (ILAs) in human amniotic fluid: a possible inhibitor of insulin‐like activity, Acta Endocrinol, 90, pp. 505-518, (1979)

[9]

Elgin RG, Busby WH, Clemmons DR., An insulin like growth factor (IGF) binding protein enhances the biologic response to IGF‐I, Proc Natl Acad Sci USA, 84, pp. 3254-3258, (1987)

[10]

Frauman AG, Tsuzaki S., Moses AC., The binding characteristics and biological effects in FRTL5 cells of placental protein‐12, an insulin‐like growth factor‐binding protein purified from human amniotic fluid, Endocrinology, 124, pp. 2289-2296, (1989)

← 1 2 3 →