ROLE OF SPECTRIN IN AMOEBA-PROTEUS, AS STUDIED BY MICROINJECTION OF ANTI-SPECTRIN MONOCLONAL-ANTIBODIES

被引：14

作者：

CHOI, EY ^{[1
]}

JEON, KW ^{[1
]}

机构：

[1] UNIV TENNESSEE,DEPT ZOOL,KNOXVILLE,TN 37996

来源：

EXPERIMENTAL CELL RESEARCH | 1992年 / 199卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0014-4827(92)90476-O

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Spectrin is a major protein accounting for about 5% of whole-cell proteins in Amoeba proteus, and the precipitation of spectrin by intracellular injection of purified anti-spectrin monoclonal antibodies has a profound effect on cell morphology, motility, and movement-related cell activities in amoebae. Thus, amoebae injected with anti-spectrin antibodies show drastic changes in their shape and movement, suggesting that amoeba spectrin plays an important structural role, unlike nonerythroid spectrins in other cells. However, precipitation of spectrin does not affect the distribution of F-actin in amoebae. © 1992.

引用

页码：174 / 178

页数：5

共 29 条

[1] Spectrin: a structural mediator between diverse plasma membrane proteins and the cytoplasm [J].