PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION OF A MOUSE INWARD RECTIFIER POTASSIUM CHANNEL

被引：971

作者：

KUBO, Y

BALDWIN, TJ

JAN, YN

JAN, LY

机构：

[1] UNIV CALIF SAN FRANCISCO,HOWARD HUGHES MED INST,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,DEPT PHYSIOL,SAN FRANCISCO,CA 94143

[3] UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM,SAN FRANCISCO,CA 94143

来源：

NATURE | 1993年 / 362卷 / 6416期

关键词：

D O I：

10.1038/362127a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A complementary DNA encoding an inward rectifier K+ channel (IRK1) was isolated from a mouse macrophage cell line by expression cloning. This channel conducts inward K+ current below the K+ equilibrium potential but passes little outward K+ current. The IRK1 channel contains only two putative transmembrane segments per subunit and corresponds to the inner core structure of voltage-gated K+ channels. The IRK1 channel and an ATP-regulated K+ channel show extensive sequence similarity and constitute a new superfamily.

引用

页码：127 / 133

页数：7

共 52 条

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