A SHORT SYNTHESIS OF N-(A)-METHYLERVITSINE - REACTIVITY OF THE INTERMEDIATE 1,4-DIHYDROPYRIDINE TOWARDS ELECTROPHILES

被引:14
作者
BENNASAR, ML [1 ]
VIDAL, B [1 ]
BOSCH, J [1 ]
机构
[1] UNIV BARCELONA,FAC PHARM,ORGAN CHEM LAB,E-08028 BARCELONA,SPAIN
关键词
D O I
10.1039/c39950000125
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A four-step synthesis of N-(a)-methylervitsine involving the nucleophilic addition of the enolate derived from acetylindole 2 to pyridinium salt 3, with subsequent C6H5SeBr-promoted cyclization of the resulting 1,4-dihydropyridine and further elaboration of the exocyclic 20E-ethylidene and 16-methylene substituents, is reported.
引用
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页码:125 / 126
页数:2
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