HUMAN P53 IS PHOSPHORYLATED BY P60-CDC2 AND CYCLIN-B-CDC2

被引：441

作者：

BISCHOFF, JR ^{[1
]}

FRIEDMAN, PN ^{[1
]}

MARSHAK, DR ^{[1
]}

PRIVES, C ^{[1
]}

BEACH, D ^{[1
]}

机构：

[1] COLUMBIA UNIV,DEPT BIOL SCI,NEW YORK,NY 10027

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 12期

关键词：

cell cycle phosphorylation; p53; recessive oncogene;

D O I：

10.1073/pnas.87.12.4766

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human anti-oncoprotein p53 is shown to be a substrate of cdc2. The primary site of phosphorylation is serine-315. Serine-315 is phosphorylated by both p60-cdc2 and cyclin B-cdc2 enzymes. The phosphorylation of p53 is cell cycle-dependent. The abundance of p53 also oscillates during the cell cycle. The protein is largely absent from cells that have just completed division but accumulates in cells during G1 phase. Phosphorylation by cdc2 might regulate the antiproliferative activity of p53.

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页码：4766 / 4770

页数：5

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