MOLECULAR-STRUCTURE OF A COMPLETE TURN OF A-DNA

被引：45

作者：

VERDAGUER, N ^{[1
]}

AYMAMI, J ^{[1
]}

FERNANDEZFORNER, D ^{[1
]}

FITA, I ^{[1
]}

COLL, M ^{[1
]}

HUYNHDINH, T ^{[1
]}

IGOLEN, J ^{[1
]}

SUBIRANA, JA ^{[1
]}

机构：

[1] INST PASTEUR,UNITE CHIM ORGAN,F-75724 PARIS,FRANCE

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1991年 / 221卷 / 02期

关键词：

DNA STRUCTURE; X-RAY DIFFRACTION; SPERMINE; A-DNA; CPG SEQUENCE;

D O I：

10.1016/0022-2836(91)80077-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have determined the crystal structure of the dodecamer d(CCCCCGCGGGGG), showing for the first time a complete turn of A-DNA. It has average structural parameters similar to those determined in fibres. Nevertheless it shows a considerable local variation in structure which is in part associated with the presence of a bound spermine molecule. We conclude that the local DNA conformation does not only depend on the base sequence, but may be strongly modified upon interaction with other molecules. In particular, the CpG sequence, which is found in hypersensitive regions of the genome, appears to be able to easily change its conformation under external influences. © 1991.

引用

页码：623 / 635

页数：13

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