SYNTHESIS AND ANTITUMOR-ACTIVITY OF SULFOALKYL DERIVATIVES OF CURDLAN AND LICHENAN

被引：34

作者：

DEMLEITNER, S ^{[1
]}

KRAUS, J ^{[1
]}

FRANZ, G ^{[1
]}

机构：

[1] UNIV REGENSBURG,INST PHARM,W-8400 REGENSBURG,GERMANY

来源：

CARBOHYDRATE RESEARCH | 1992年 / 226卷 / 02期

关键词：

D O I：

10.1016/0008-6215(92)84072-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2-Sulfoethyl, 3-sulfopropyl, and 4-sulfobutyl derivatives of the (1 --> 3)-beta-D-glucan curdlan and the (1 --> 3/1 --> 4)-beta-D-glucan lichenan have been synthesised. The substituents are located mainly at positions 6. The curdlan derivatives strongly inhibited the growth of the Sarcoma 180 tumour, whereas the lichenan derivatives were inactive, indicating that a (1 --> 3)-linked beta-D-glucan backbone is essential for activity.

引用

页码：247 / 252

页数：6

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