CHARACTERISTICS AND SUBCELLULAR-LOCALIZATION OF PRISTANOYL-COA SYNTHETASE IN RAT-LIVER

被引：32

作者：

WANDERS, RJA

DENIS, S

VANROERMUND, CWT

JAKOBS, C

TENBRINK, HJ

机构：

[1] UNIV AMSTERDAM,ACAD MED CTR,DEPT CLIN BIOCHEM FO226,1105 AZ AMSTERDAM,NETHERLANDS

[2] FREE UNIV AMSTERDAM,DEPT PEDIAT,1007 MC AMSTERDAM,NETHERLANDS

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1125卷 / 03期

关键词：

PRISTANIC ACID; PHYTANIC ACID; PEROXISOME; PEROXISOMAL DISORDER; FATTY ACID OXIDATION; (RAT LIVER);

D O I：

10.1016/0005-2760(92)90056-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have investigated the activation of pristanic acid to its CoA-ester in rat liver. The results show that peroxisomes, mitochondria as well as microsomes contain pristanoyl-CoA synthetase activity. On the basis of competition experiments and immunoprecipitation studies using antibodies raised against rat liver microsomal long-chain fatty acyl-CoA synthetase (EC 6.2.1.3) we conclude that pristanic acid is activated by the same enzyme which activates long-chain fatty acids, i.e., long-chain fatty acyl-CoA synthetase.

引用

页码：274 / 279

页数：6

共 34 条

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