Amphotericin B delays the onset of clinical symptoms in hamsters infected with scrapie agent strain 263K. Here we show that accumulation of a scrapie-specific isoform of the prion protein (PrP-res) and agent replication were delayed early in amphotericin B-treated animals. By 8 weeks postinfection, only untreated animals exhibited clinical symptoms of scrapie infection whereas PrP-res levels and titers were similar in treated and untreated animals. This suggests that although PrP-res accumulation and agent replication are linked, they are not the sole factors required for the onset of clinical disease.
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NEW YORK STATE OFF MENTAL RETARDAT & DEV DISABIL,INST BASIC RES,DEPT PATHOL NEUROBIOL,STATEN ISL,NY 10314NEW YORK STATE OFF MENTAL RETARDAT & DEV DISABIL,INST BASIC RES,DEPT PATHOL NEUROBIOL,STATEN ISL,NY 10314
BOLTON, DC
BENDHEIM, PE
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NEW YORK STATE OFF MENTAL RETARDAT & DEV DISABIL,INST BASIC RES,DEPT PATHOL NEUROBIOL,STATEN ISL,NY 10314NEW YORK STATE OFF MENTAL RETARDAT & DEV DISABIL,INST BASIC RES,DEPT PATHOL NEUROBIOL,STATEN ISL,NY 10314
BENDHEIM, PE
MARMORSTEIN, AD
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NEW YORK STATE OFF MENTAL RETARDAT & DEV DISABIL,INST BASIC RES,DEPT PATHOL NEUROBIOL,STATEN ISL,NY 10314NEW YORK STATE OFF MENTAL RETARDAT & DEV DISABIL,INST BASIC RES,DEPT PATHOL NEUROBIOL,STATEN ISL,NY 10314
MARMORSTEIN, AD
POTEMPSKA, A
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NEW YORK STATE OFF MENTAL RETARDAT & DEV DISABIL,INST BASIC RES,DEPT PATHOL NEUROBIOL,STATEN ISL,NY 10314NEW YORK STATE OFF MENTAL RETARDAT & DEV DISABIL,INST BASIC RES,DEPT PATHOL NEUROBIOL,STATEN ISL,NY 10314
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UNIV CALIF SAN FRANCISCO, DEPT BIOCHEM & BIOPHYS, SAN FRANCISCO, CA 94143 USAUNIV CALIF SAN FRANCISCO, DEPT BIOCHEM & BIOPHYS, SAN FRANCISCO, CA 94143 USA
BOLTON, DC
MCKINLEY, MP
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UNIV CALIF SAN FRANCISCO, DEPT BIOCHEM & BIOPHYS, SAN FRANCISCO, CA 94143 USAUNIV CALIF SAN FRANCISCO, DEPT BIOCHEM & BIOPHYS, SAN FRANCISCO, CA 94143 USA
MCKINLEY, MP
PRUSINER, SB
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UNIV CALIF SAN FRANCISCO, DEPT BIOCHEM & BIOPHYS, SAN FRANCISCO, CA 94143 USAUNIV CALIF SAN FRANCISCO, DEPT BIOCHEM & BIOPHYS, SAN FRANCISCO, CA 94143 USA
机构:
NEW YORK STATE OFF MENTAL RETARDAT & DEV DISABIL,INST BASIC RES,DEPT PATHOL NEUROBIOL,STATEN ISL,NY 10314NEW YORK STATE OFF MENTAL RETARDAT & DEV DISABIL,INST BASIC RES,DEPT PATHOL NEUROBIOL,STATEN ISL,NY 10314
BOLTON, DC
BENDHEIM, PE
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h-index: 0
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NEW YORK STATE OFF MENTAL RETARDAT & DEV DISABIL,INST BASIC RES,DEPT PATHOL NEUROBIOL,STATEN ISL,NY 10314NEW YORK STATE OFF MENTAL RETARDAT & DEV DISABIL,INST BASIC RES,DEPT PATHOL NEUROBIOL,STATEN ISL,NY 10314
BENDHEIM, PE
MARMORSTEIN, AD
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h-index: 0
机构:
NEW YORK STATE OFF MENTAL RETARDAT & DEV DISABIL,INST BASIC RES,DEPT PATHOL NEUROBIOL,STATEN ISL,NY 10314NEW YORK STATE OFF MENTAL RETARDAT & DEV DISABIL,INST BASIC RES,DEPT PATHOL NEUROBIOL,STATEN ISL,NY 10314
MARMORSTEIN, AD
POTEMPSKA, A
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NEW YORK STATE OFF MENTAL RETARDAT & DEV DISABIL,INST BASIC RES,DEPT PATHOL NEUROBIOL,STATEN ISL,NY 10314NEW YORK STATE OFF MENTAL RETARDAT & DEV DISABIL,INST BASIC RES,DEPT PATHOL NEUROBIOL,STATEN ISL,NY 10314
机构:
UNIV CALIF SAN FRANCISCO, DEPT BIOCHEM & BIOPHYS, SAN FRANCISCO, CA 94143 USAUNIV CALIF SAN FRANCISCO, DEPT BIOCHEM & BIOPHYS, SAN FRANCISCO, CA 94143 USA
BOLTON, DC
MCKINLEY, MP
论文数: 0引用数: 0
h-index: 0
机构:
UNIV CALIF SAN FRANCISCO, DEPT BIOCHEM & BIOPHYS, SAN FRANCISCO, CA 94143 USAUNIV CALIF SAN FRANCISCO, DEPT BIOCHEM & BIOPHYS, SAN FRANCISCO, CA 94143 USA
MCKINLEY, MP
PRUSINER, SB
论文数: 0引用数: 0
h-index: 0
机构:
UNIV CALIF SAN FRANCISCO, DEPT BIOCHEM & BIOPHYS, SAN FRANCISCO, CA 94143 USAUNIV CALIF SAN FRANCISCO, DEPT BIOCHEM & BIOPHYS, SAN FRANCISCO, CA 94143 USA