AMPHOTERICIN-B DELAYS BOTH SCRAPIE AGENT REPLICATION AND PRP-RES ACCUMULATION EARLY IN INFECTION

被引:49
作者
MCKENZIE, D
KACZKOWSKI, J
MARSH, R
AIKEN, J
机构
关键词
D O I
10.1128/JVI.68.11.7534-7536.1994
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Amphotericin B delays the onset of clinical symptoms in hamsters infected with scrapie agent strain 263K. Here we show that accumulation of a scrapie-specific isoform of the prion protein (PrP-res) and agent replication were delayed early in amphotericin B-treated animals. By 8 weeks postinfection, only untreated animals exhibited clinical symptoms of scrapie infection whereas PrP-res levels and titers were similar in treated and untreated animals. This suggests that although PrP-res accumulation and agent replication are linked, they are not the sole factors required for the onset of clinical disease.
引用
收藏
页码:7534 / 7536
页数:3
相关论文
共 19 条
  • [1] IDENTIFICATION OF 2 BIOLOGICALLY DISTINCT STRAINS OF TRANSMISSIBLE MINK ENCEPHALOPATHY IN HAMSTERS
    BESSEN, RA
    MARSH, RF
    [J]. JOURNAL OF GENERAL VIROLOGY, 1992, 73 : 329 - 334
  • [2] BIOCHEMICAL AND PHYSICAL-PROPERTIES OF THE PRION PROTEIN FROM 2 STRAINS OF THE TRANSMISSIBLE MINK ENCEPHALOPATHY AGENT
    BESSEN, RA
    MARSH, RF
    [J]. JOURNAL OF VIROLOGY, 1992, 66 (04) : 2096 - 2101
  • [3] ISOLATION AND STRUCTURAL STUDIES OF THE INTACT SCRAPIE AGENT PROTEIN
    BOLTON, DC
    BENDHEIM, PE
    MARMORSTEIN, AD
    POTEMPSKA, A
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1987, 258 (02) : 579 - 590
  • [4] IDENTIFICATION OF A PROTEIN THAT PURIFIES WITH THE SCRAPIE PRION
    BOLTON, DC
    MCKINLEY, MP
    PRUSINER, SB
    [J]. SCIENCE, 1982, 218 (4579) : 1309 - 1311
  • [5] Bruce M E, 1991, Curr Top Microbiol Immunol, V172, P125
  • [6] PRECISE TARGETING OF THE PATHOLOGY OF THE SIALOGLYCOPROTEIN, PRP, AND VACUOLAR DEGENERATION IN MOUSE SCRAPIE
    BRUCE, ME
    MCBRIDE, PA
    FARQUHAR, CF
    [J]. NEUROSCIENCE LETTERS, 1989, 102 (01) : 1 - 6
  • [7] REPLICATION OF THE SCRAPIE AGENT IN HAMSTERS INFECTED INTRACEREBRALLY CONFIRMS THE PATHOGENESIS OF AN AMYLOID-INDUCING VIROSIS
    CZUB, M
    BRAIG, HR
    DIRINGER, H
    [J]. JOURNAL OF GENERAL VIROLOGY, 1988, 69 : 1753 - 1756
  • [8] PRO-]LEU CHANGE AT POSITION-102 OF PRION PROTEIN IS THE MOST COMMON BUT NOT THE SOLE MUTATION RELATED TO GERSTMANN-STRAUSSLER SYNDROME
    DOHURA, K
    TATEISHI, J
    SASAKI, H
    KITAMOTO, T
    SAKAKI, Y
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 163 (02) : 974 - 979
  • [9] MUTATIONS IN FAMILIAL CREUTZFELDT-JAKOB DISEASE AND GERSTMANN-STRAUSSLER-SCHEINKERS SYNDROME
    GOLDGABER, D
    GOLDFARB, LG
    BROWN, P
    ASHER, DM
    BROWN, WT
    LIN, S
    TEENER, JW
    FEINSTONE, SM
    RUBENSTEIN, R
    KASCSAK, RJ
    BOELLAARD, JW
    GAJDUSEK, DC
    [J]. EXPERIMENTAL NEUROLOGY, 1989, 106 (02) : 204 - 206
  • [10] LINKAGE OF THE SCRAPIE-ASSOCIATED FIBRIL PROTEIN (PRP) GENE AND SINC USING CONGENIC MICE AND RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM ANALYSIS
    HUNTER, N
    HOPE, J
    MCCONNELL, I
    DICKINSON, AG
    [J]. JOURNAL OF GENERAL VIROLOGY, 1987, 68 : 2711 - 2716