THE OXIDATION OF LOW-DENSITY-LIPOPROTEIN BY CELLS OR IRON IS INHIBITED BY ZINC

被引：47

作者：

WILKINS, GM

LEAKE, DS

机构：

[1] Department of Biochemistry and Physiology, University of Reading, Whiteknights, Reading, Berkshire RG6 2AJ

来源：

FEBS LETTERS | 1994年 / 341卷 / 2-3期

基金：

英国惠康基金;

关键词：

ATHEROSCLEROSIS; ENDOTHELIAL CELL; IRON; LOW DENSITY LIPOPROTEIN; MACROPHAGE; ZINC;

D O I：

10.1016/0014-5793(94)80468-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have examined the effect of zinc ions on low density lipoprotein (LDL) oxidation by macrophages, endothelial cells and iron ions in terms of the increased uptake of the LDL by macrophages. Zinc ions inhibited LDL modification by both cell types (which is dependent on the presence of iron ions in the culture medium) and by iron ions alone. As oxidised LDL is believed to be involved in atherogenesis, this raises the possibility that zinc may be an endogenous protective factor against atherosclerosis.

引用

收藏

页码：259 / 262

页数：4

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