TRANSMISSION OF PSEUDORABIES VIRUS WITHIN PIG-POPULATIONS IS INDEPENDENT OF THE SIZE OF THE POPULATION

被引:76
作者
BOUMA, A [1 ]
DEJONG, MCM [1 ]
KIMMAN, TG [1 ]
机构
[1] UNIV UTRECHT,DEPT HERD HLTH & REPROD,UTRECHT,NETHERLANDS
关键词
POPULATION SIZE; EPIDEMIOLOGY; PSEUDORABIES VIRUS; TRANSMISSION;
D O I
10.1016/0167-5877(94)00442-L
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Epidemic models are often used to analyse the transmission of infectious diseases. These models, however, differ in whether they assume that transmission of a pathogen increases with population size or not. The purpose of this study was to investigate whether the transmission of pseudorabies virus-expressed as the reproduction ratio R-depends on population size. Experimental groups of either ten or 40 vaccinated pigs per group were housed at equal density. We inoculated half of each group, and we estimated the transmission of the virus from the number of contact-infections, using a stochastic Susceptible-Infectious-Recovered model. We calculated that if the transmission depended on population size, the transmission in the group of 40 pigs would be four times as high as the transmission in the group of ten pigs. However, the transmission of the virus did not differ significantly between the groups, and thus we concluded that the transmission was not influenced by the size of the population This finding suggests that control measures should not be aimed at reducing the size of the herd.
引用
收藏
页码:163 / 172
页数:10
相关论文
共 23 条
  • [1] Anderson, The concept of herd immunity and the design of community-based immunization programmes, Vaccine, 10, pp. 928-935, (1992)
  • [2] Anderson, May, Population biology of infectious diseases, Nature, 280, pp. 361-367, (1979)
  • [3] Handboekje voor de Varkenshouderij, (1985)
  • [4] Becker, Analysis of Infectious Data, pp. 139-174, (1989)
  • [5] De Jong, Kimman, Experimental quantification of vaccine-induced reduction in virus transmission, Vaccine, 12, pp. 761-766, (1994)
  • [6] De Jong, Diekmann, Heesterbeek, How does transmission depend on population size?, Epidemic Models: Their Structure and Relation to Data, (1994)
  • [7] Diekmann, Heesterbeek, Metz, On the definition and computation of the basic reproduction ratio R0 in models for infectious diseases in heterogeneous populations, J. Math. Biol., 28, pp. 365-382, (1990)
  • [8] Fox, Elveback, Scott, Gatewood, Ackerman, Herd immunity: basic concept and relevance to public health immunization practices, Ara. J. Epidemiol., 94, pp. 179-189, (1971)
  • [9] Gao, Hethcote, Disease transmission models with density-dependent demographics, J. Math. Biol., 30, pp. 717-731, (1992)
  • [10] Gielkens, Moormann, van Oirschot, Berns, Vaccine efficacy and innocuity of strain 783 of Aujeszky's disease virus, Vaccination and Control of Aujeszky's Disease, pp. 27-35, (1989)