DIVERSITY AMONG LEISHMANIA ISOLATES FROM THE SUDAN - ISOENZYME HOMOGENEITY OF LEISHMANIA-DONOVANI VERSUS HETEROGENEITY OF L-MAJOR

被引：12

作者：

IBRAHIM, ME

EVANS, DA

THEANDER, TG

ELHASSAN, AM

KHARAZMI, A

机构：

[1] UNIV COPENHAGEN,CTR MED PARASITOL,COPENHAGEN,DENMARK

[2] NATL UNIV HOSP,COPENHAGEN,DENMARK

[3] UNIV LONDON LONDON SCH HYG & TROP MED,DEPT MED PARASITOL,LONDON WC1E 7HT,ENGLAND

[4] UNIV KHARTOUM,INST ENDEM DIS,KHARTOUM,SUDAN

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1995年 / 89卷 / 04期

关键词：

LEISHMANIASIS; LEISHMANIA DONOVANI; LEISHMANIC TROPICA; ZYMODEMES; SUDAN;

D O I：

10.1016/0035-9203(95)90010-1

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Leishmania isolates from patients in the Sudan suffering from either visceral or cutaneous leishmaniasis were characterized using a battery of 12 enzymes. Aspartate aminotransferase separated the L. donovani isolates into 2 distinct zymodemes, but the overall results showed no significant geographical variation among L. donovani isolates. In contrast, the isolates of L. major were polymorphic, exhibiting differences in nucleoside hydrolase, 6-phosphogluconate dehydrogenase, superoxide dismutase, esterase, mannose phosphate isomerase, and aspartate aminotransferase, resulting in the description of 4 new enzymatic variants.

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页码：366 / 369

页数：4

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