TEMPERATURE-DEPENDENCE OF TRACHEAL SMOOTH-MUSCLE RESPONSE TO ISOPROTERENOL

被引：9

作者：

DOWNING, D ^{[1
]}

KOLBECK, RC ^{[1
]}

HOLL, JE ^{[1
]}

BRANSOME, ED ^{[1
]}

SPEIR, WA ^{[1
]}

机构：

[1] UNIV GEORGIA,DEPT PHARMACOL,ATHENS,GA 30602

来源：

LIFE SCIENCES | 1979年 / 24卷 / 07期

关键词：

D O I：

10.1016/0024-3205(79)90156-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

An inverse relationship between temperature and the negative inotropic response of tracheal smooth muscle segments to isoproterenol was demonstrated at resting tension and following precontraction with histamine. In addition, the β-blocking effect of propranolol was more pronounced at higher temperatures. These findings suggest that in asthmatic patients fever might be one of the factors which contribute to diminished responsiveness of sympathomimetic bronchodilators. © 1979.

引用

页码：603 / 607

页数：5

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