ZOLPIDEM INTOXICATION MIMICKING NARCOTIC OVERDOSE - RESPONSE TO FLUMAZENIL

被引：31

作者：

LHEUREUX, P

DEBAILLEUL, G

DEWITTE, O

ASKENASI, R

机构：

[1] ERASME UNIV HOSP,CLIN TOXICOL UNIT,B-1070 BRUSSELS,BELGIUM

[2] ERASME UNIV HOSP,CENT LAB TOXICOL,B-1070 BRUSSELS,BELGIUM

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 1990年 / 9卷 / 02期

关键词：

D O I：

10.1177/096032719000900209

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Zolpidem is a recently introduced sleep-inducer which is thought to act on the central-type benzodiazepine receptors. This observation is the first report of drug poisoning with this compound. The toxic response was characterized by the development of a profound but short-lasting coma, associated with pin-point pupils and respiratory depression, as observed in a narcotic overdose. These clinical signs were not influenced by the administration of naloxone, but responded dramatically to flumazenil. Some analytical data on zolpidem toxicokinetics are presented. © 1990, Sage Publications. All rights reserved.

引用

页码：105 / 107

页数：3

共 21 条

[1] PHARMACOLOGICAL PROFILE OF THE IMIDAZOPYRIDINE ZOLPIDEM AT BENZODIAZEPINE RECEPTORS AND ELECTROCORTICOGRAM IN RATS [J].