AN IMPROVED METHOD FOR THE ANALYSIS OF DATA FROM RADIATION-INACTIVATION STUDIES

被引:2
作者
BRADBURY, I
ZAMMIT, VA
机构
[1] HANNAH RES INST,AYR KA6 5HL,SCOTLAND
[2] SCOTTISH AGR STAT SERV,EDINBURGH,SCOTLAND
关键词
D O I
10.1016/0003-2697(90)90075-K
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
This paper addresses statistical issues in the estimation of protein molecular weight using radiation-inactivation assays. In particular it considers experiments in which a number of internal standards are used to supplement or replace accurate measurement of the applied doses of radiation. A mathematical model is proposed which allows the use of the standard technique of maximum-likelihood estimation to estimate the unknown molecular weight without knowledge of the applied doses and, in contrast to previous methods, allows the construction of confidence intervals. © 1990.
引用
收藏
页码:251 / 256
页数:6
相关论文
共 13 条
[1]  
AUGENSTEIN LG, 1963, PROG BIOPHYS MOL BIO, V13, P3
[2]  
JUNG CY, 1984, MOL CHEM CHARACTERIZ, P193
[3]  
KALBFLEI.JD, 1970, J ROY STAT SOC B, V32, P175
[4]  
KEMPNER ES, 1979, ANAL BIOCHEM, V92, P2, DOI 10.1016/0003-2697(79)90617-1
[5]  
KEMPNER ES, 1968, BIOCHIM BIOPHYS ACTA, V163, P188
[6]  
LAI FA, 1987, TARGET SIZE ANAL MEM, P33
[7]   SIZE OF ACETYLCHOLINE-RECEPTORS IN THE MEMBRANE - AN IMPROVED VERSION OF THE RADIATION INACTIVATION METHOD [J].
LO, MMS ;
BARNARD, EA ;
DOLLY, JO .
BIOCHEMISTRY, 1982, 21 (09) :2210-2217
[8]   MOLECULAR-SIZE STANDARDS FOR USE IN RADIATION-INACTIVATION STUDIES ON PROTEINS [J].
NUGENT, JHA .
BIOCHEMICAL JOURNAL, 1986, 239 (02) :459-462
[9]   THE DIRECT ACTION OF IONIZING RADIATION ON ENZYMES AND ANTIGENS [J].
POLLARD, EC ;
GUILD, WR ;
HUTCHINSON, F ;
SETLOW, RB .
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1955, 5 :72-108
[10]  
SCHLEGEL W, 1979, J BIOL CHEM, V254, P5168