ANTAGONISTIC EFFECT OF THE ANTIESTROGEN 4-HYDROXYTAMOXIFEN ON ESTRADIOL-STIMULATED ACETYLATION OF NUCLEAR HIGH MOBILITY GROUP (HMG) PROTEINS IN THE UTERUS OF NEWBORN GUINEA-PIGS

被引：2

作者：

BERTRANDMERCAT, P ^{[1
]}

PASQUALINI, JR ^{[1
]}

机构：

[1] FDN HORMONE RES,CNRS,STEROID HORMONE RES UNIT,26 BLVD BRUNE,F-75014 PARIS,FRANCE

来源：

LIFE SCIENCES | 1991年 / 48卷 / 21期

关键词：

D O I：

10.1016/0024-3205(91)90165-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of the antiestrogen 4-hydroxytamoxifen on the estradiol-stimulated acetylation of nuclear high mobility group (HMG) proteins was studied in the uterus of newborn (3-day-old) guinea-pig. 4-Hydroxytamoxifen (10(-6) M) selectively inhibits the stimulatory effect of estradiol (5 x 10(-8) M) on the acetylation of HMG-14 proteins 30 min after incubation with uterine tissue slices. No effect of 4-hydroxytamoxifen was observed on HMG-1 + HMG-2 or HMG-17 proteins. The data suggest that the blockage of HMG-14 acetylation is an early event in gene expression which is in relation to the antagonistic effect of the antiestrogen.

引用

页码：2081 / 2087

页数：7