PREDOMINANCE OF RESISTANT ORAL STREPTOCOCCI IN SALIVA AND THE EFFECT OF A SINGLE COURSE OF JOSAMYCIN OR ERYTHROMYCIN

被引:20
作者
MASKELL, JP [1 ]
SEFTON, AM [1 ]
CANNELL, H [1 ]
KERAWALA, C [1 ]
SEYMOUR, A [1 ]
SUN, ZM [1 ]
WILLIAMS, JD [1 ]
机构
[1] UNIV LONDON LONDON HOSP,COLL MED,DEPT ORAL & MAXILLOFACIAL SURG,LONDON E1 2AD,ENGLAND
关键词
D O I
10.1093/jac/26.4.539
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
We have investigated the influence of the macrolides erythromycin and josamycin on the selection of resistant oral streptococci by sampling saliva of volunteers before and ofter oral administration of 1.5 g of either agent followed by a further 0.5 g of the same drug after 6 h, as in routine prophylaxis for oral or dental procedures. The small proportion of resistant organisms present before antibiotic administration increased substantially 48 h after the macrolides were given. After antibiotic administration mean counts of oral streptococci resistant to 1, 4 and 64 mg/l erythromycin were 23%, 17% and 6%, respectively, of the total numbers of streptococci isolated; after josamycin, the values were 13%, 6% and 4% respectively. The proportion of resistant streptococci then declined gradually but remained above pre-antibiotic levels three months later. Streptococci isolated on media containing 64 mg/l of macrolides were mainly Streptococcus sanguis and S. mitis with one isolate of S. salivarius, the majority were resistant to 256 mg/l erythromycin, josamycin, all other macrolides tested and clindamydn. Amoxycillin and pristinamycin were the only compounds tested that were inhibitory to these organisms at therapeutically attainable concentrations. © 1990 by The British Society for Antimicrobial Chemotherapy.
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页码:539 / 548
页数:10
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