SYNAPTIC N-METHYL-D-ASPARTATE RECEPTORS IN THE NEONATAL RAT VISUAL-CORTEX ARE LESS SENSITIVE TO MK-801 THAN IN ADULT

被引：15

作者：

KATO, N

机构：

[1] Department of Integrative Brain Science, Faculty of Medicine, Kyoto University, Kyoto

来源：

BRAIN RESEARCH | 1993年 / 608卷 / 01期

关键词：

N-METHYL-D-ASPARTATE RECEPTOR; DEVELOPMENT; RAT; MK-801; SYNAPTIC POTENTIAL; GLUTAMATE RECEPTOR;

D O I：

10.1016/0006-8993(93)90790-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The excitatory postsynaptic potential mediated by N-methyl-D-aspartate (NMDA) receptors (NMDA-EPSP) was intracellularly obtained in slices from the visual cortex of adult and 2-week-old rats. Bath application of 0.3 muM (+)-MK-801, an NMDA receptor open-channel blocker, completely blocked NMDA-EPSPs in slices from adult rats. By contrast, in slices from the younger rats, a 10 muM solution was needed for the complete blockade. This difference in sensitivity to an open-channel blocker implies a major developmental change in the conformation of NMDA receptors in situ.

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收藏

页码：166 / 168

页数：3

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