QUALITY-OF-LIFE AND ANTIHYPERTENSIVE DRUGS IN THE ELDERLY

被引：9

作者：

FLETCHER, A

BULPITT, C

机构：

[1] Epidemiology Research Unit, Division of Geriatric Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, W12 OHS, Du Cane Road

来源：

AGING-CLINICAL AND EXPERIMENTAL RESEARCH | 1992年 / 4卷 / 02期

关键词：

ANTIHYPERTENSIVE DRUGS; ELDERLY; QUALITY OF LIFE;

D O I：

10.1007/BF03324077

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Hypertension is common in the elderly with estimates of around 10-20% showing a sustained level of pressure, either systolic (greater-than-or-equal-to 160 mmHg), or diastolic (greater-than-or-equal-to 90 mmHg) or both. The benefits of treating subjects with raised diastolic pressure was shown by the trials of the European Working Party on High Blood Pressure in the Elderly (EWPHE), the Hypertension in Elderly Patients in Primary Care (HEP), and the Swedish Trial in Old patients with Hypertension (STOP-Hypertension). Evidence for the benefit of treating isolated systolic hypertension in the elderly was provided in one trial (SHEP: Systolic Hypertension in the Elderly Program), and the results of two others are awaited. However, it is important to provide data on all treatment effects, including adverse reactions as well as benefits. In addition to traditional measures of mortality, morbidity and side effects, the quality of life in patients on antihypertensive treatment should be considered. The methods of measuring quality of life in trials is discussed, and some results presented.

引用

页码：115 / 123

页数：9

共 55 条

[1]

Bulpitt C.J., Definition, prevalence and incidence of hypertension in the elderly, Handbook of Hypertension. Hypertension in the Elderly, Vol. 12, pp. 153-169, (1989)

[2]

McMahon S., Peto R., Cutler J., Collins R., Sorlie P., Neaton J., Abbott R., Godwin J., Dyer A., Stamber J., Blood pressure, stroke and coronary heart disease. Part 1. Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias, Lancet, 335, pp. 765-774, (1990)

[3]

Harris T., Cook E.F., Kannel W.B., Goldman L., Proportional hazards analysis of risk factors for coronary heart disease in individuals aged 65 or older. The Framingham Heart Study, J. Am. Geriatr. Soc., 36, pp. 1023-1028, (1988)

[4]

Colandrea M.A., Friedman G.D., Nichaman M.Z., Lynd C.N., Systolic hypertension in the elderly: an epidemiologic assessment, Circulation, 41, pp. 239-245, (1970)

[5]

Kannel W.B., Dawber T.R., McGee D.L., Perspectives on systolic hypertension: the Framingham Study, Circulation, 61, pp. 1179-1182, (1980)

[6]

Forette F., De La Fuente X., Golmard J.L., Henry J.F., Hervy M.P., The prognostic significance of isolated systolic hypertension in the elderly: results of a ten year longitudinal survey, Clin. Exp. Hypertens., 4, pp. 1177-1191, (1982)

[7]

Rutan G.H., Kuller L.H., Neaton J.D., Wentworth D.N., McDonald R.H., McFate Smith W., Mortality associated with diastolic hypertension and isolated systolic hypertension among men screened for the Multiple Risk Factor Intervention Trial, Circulation, 77, pp. 504-514, (1988)

[8]

Garland C., Barrett-Connor E., Suarez L., Criqui M.H., Isolated systolic hypertension and mortality after age 60 years: a prospective population-based study, Am. J. Epidemiol., 118, pp. 365-376, (1983)

[9]

Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the Elderly Program (SHEP), JAMA, 265, pp. 3255-3264, (1991)

[10]

Amery A., Birkenhager W., Bulpitt C.J., Clement D., De Leeuw P., Dollery C.T., Fagard R., Fletcher A., Forette F., Leonetti G., O'Brien E.T., O'Malley K., Rodicio J.L., Rosenfeld J., Staessen J., Strasser T., Terzoli L., Thijs L., Tuomilehto J., Webster J., Syst-Eur. A multicentre trial on the treatment of isolated systolic hypertension in the elderly: Objectives, protocol and organization, Aging Clin. Exp. Res., 3, pp. 287-302, (1991)

← 1 2 3 4 5 6 →