LONG-RANGE CIS PREFERENCE IN DNA HOMOLOGY SEARCH OVER THE LENGTH OF A DROSOPHILA CHROMOSOME

被引：53

作者：

ENGELS, WR

PRESTON, CR

JOHNSONSCHLITZ, DM

机构：

[1] Genetics Department, University of Wisconsin, Madison

来源：

SCIENCE | 1994年 / 263卷 / 5153期

关键词：

D O I：

10.1126/science.8128250

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

P element-induced chromosome breakage on the X chromosome of Drosophila melanogaster was repaired six times more frequently when a homologous template was located anywhere on the X chromosome rather than on an autosome. Cis-trans comparisons confirmed that recombinational repair was more frequent when the interacting sequences were physically connected. These results suggest that the search for homology between the broken ends and a matching template sequence occurs preferentially in the cis configuration. This cis advantage operates over more than 15 megabases of DNA.

引用

页码：1623 / 1625

页数：3

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