共 28 条
T-CELL UNRESPONSIVENESS CORRELATES WITH QUANTITATIVE TCR LEVELS IN A TRANSGENIC MODEL
被引:19
作者:

HOMER, RJ
论文数: 0 引用数: 0
h-index: 0
机构: YALE UNIV, SCH MED, IMMUNOBIOL SECT, NEW HAVEN, CT 06510 USA

MAMALAKI, C
论文数: 0 引用数: 0
h-index: 0
机构: YALE UNIV, SCH MED, IMMUNOBIOL SECT, NEW HAVEN, CT 06510 USA

KIOUSSIS, D
论文数: 0 引用数: 0
h-index: 0
机构: YALE UNIV, SCH MED, IMMUNOBIOL SECT, NEW HAVEN, CT 06510 USA

FLAVELL, RA
论文数: 0 引用数: 0
h-index: 0
机构: YALE UNIV, SCH MED, IMMUNOBIOL SECT, NEW HAVEN, CT 06510 USA
机构:
[1] YALE UNIV, SCH MED, IMMUNOBIOL SECT, NEW HAVEN, CT 06510 USA
[2] NATL INST MED RES, LONDON NW7 1AA, ENGLAND
[3] YALE UNIV, SCH MED, HOWARD HUGHES MED INST, NEW HAVEN, CT 06510 USA
关键词:
T-CELL DEVELOPMENT;
TCR GENETICS;
TOLERANCE;
TRANSGENIC ANIMAL MOUSE;
D O I:
10.1093/intimm/5.12.1495
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Two lines of transgenic mice were developed which differ in their level of expression of V(beta)11. To determine the role of TCR density in tolerance induction, these mice were bred with I-E expressing mice and were investigated for tolerance induction. T cells expressing V(beta)11 at high density are deleted by negative selection. T cells expressing < 10% of the normal TCR receptor density are not subject to negative selection and were not activated in vitro. There is a correlation in receptor density in both strains of mice with in vitro activation. These findings support the notion that there is a definable quantitative signal threshold which is critical for tolerance induction.
引用
收藏
页码:1495 / 1500
页数:6
相关论文
共 28 条
- [1] INFLUENCE OF ANTIGEN DENSITY ON DEGREE OF CLONAL DELETION IN T-CELL RECEPTOR TRANSGENIC MICE[J]. INTERNATIONAL IMMUNOLOGY, 1992, 4 (04) : 541 - 547AUPHAN, N论文数: 0 引用数: 0 h-index: 0机构: Centre d'lmmunologie INSERM-CNRS de Marseille-Luminy, Parc Scientifique de Luminy, 13288 Marseille Cedex 9SCHONRICH, G论文数: 0 引用数: 0 h-index: 0机构: Centre d'lmmunologie INSERM-CNRS de Marseille-Luminy, Parc Scientifique de Luminy, 13288 Marseille Cedex 9MALISSEN, M论文数: 0 引用数: 0 h-index: 0机构: Centre d'lmmunologie INSERM-CNRS de Marseille-Luminy, Parc Scientifique de Luminy, 13288 Marseille Cedex 9BARAD, M论文数: 0 引用数: 0 h-index: 0机构: Centre d'lmmunologie INSERM-CNRS de Marseille-Luminy, Parc Scientifique de Luminy, 13288 Marseille Cedex 9HAMMERLING, G论文数: 0 引用数: 0 h-index: 0机构: Centre d'lmmunologie INSERM-CNRS de Marseille-Luminy, Parc Scientifique de Luminy, 13288 Marseille Cedex 9ARNOLD, B论文数: 0 引用数: 0 h-index: 0机构: Centre d'lmmunologie INSERM-CNRS de Marseille-Luminy, Parc Scientifique de Luminy, 13288 Marseille Cedex 9MALISSEN, B论文数: 0 引用数: 0 h-index: 0机构: Centre d'lmmunologie INSERM-CNRS de Marseille-Luminy, Parc Scientifique de Luminy, 13288 Marseille Cedex 9SCHMITTVERHULST, AM论文数: 0 引用数: 0 h-index: 0机构: Centre d'lmmunologie INSERM-CNRS de Marseille-Luminy, Parc Scientifique de Luminy, 13288 Marseille Cedex 9
- [2] THE MHC MOLECULE I-E IS NECESSARY BUT NOT SUFFICIENT FOR THE CLONAL DELETION OF V-BETA-11-BEARING T-CELLS[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (04) : 1405 - 1419BILL, J论文数: 0 引用数: 0 h-index: 0机构: NATL JEWISH CTR IMMUNOL & RESP MED,DEPT PEDIAT,DIV BASIC SCI,DENVER,CO 80206KANAGAWA, O论文数: 0 引用数: 0 h-index: 0机构: NATL JEWISH CTR IMMUNOL & RESP MED,DEPT PEDIAT,DIV BASIC SCI,DENVER,CO 80206WOODLAND, DL论文数: 0 引用数: 0 h-index: 0机构: NATL JEWISH CTR IMMUNOL & RESP MED,DEPT PEDIAT,DIV BASIC SCI,DENVER,CO 80206PALMER, E论文数: 0 引用数: 0 h-index: 0机构: NATL JEWISH CTR IMMUNOL & RESP MED,DEPT PEDIAT,DIV BASIC SCI,DENVER,CO 80206
- [3] T-CELL TOLERANCE BY CLONAL ANERGY IN TRANSGENIC MICE WITH NONLYMPHOID EXPRESSION OF MHC CLASS-II I-E[J]. NATURE, 1989, 342 (6249) : 564 - 566BURKLY, LC论文数: 0 引用数: 0 h-index: 0机构: UNIV PENN,SCH VET MED,REPROD PHYSIOL LAB,PHILADELPHIA,PA 19104LO, D论文数: 0 引用数: 0 h-index: 0机构: UNIV PENN,SCH VET MED,REPROD PHYSIOL LAB,PHILADELPHIA,PA 19104KANAGAWA, O论文数: 0 引用数: 0 h-index: 0机构: UNIV PENN,SCH VET MED,REPROD PHYSIOL LAB,PHILADELPHIA,PA 19104BRINSTER, RL论文数: 0 引用数: 0 h-index: 0机构: UNIV PENN,SCH VET MED,REPROD PHYSIOL LAB,PHILADELPHIA,PA 19104FLAVELL, RA论文数: 0 引用数: 0 h-index: 0机构: UNIV PENN,SCH VET MED,REPROD PHYSIOL LAB,PHILADELPHIA,PA 19104
- [4] HUMAN CD2 3'-FLANKING SEQUENCES CONFER HIGH-LEVEL, T-CELL-SPECIFIC, POSITION-INDEPENDENT GENE-EXPRESSION IN TRANSGENIC MICE[J]. CELL, 1989, 56 (06) : 979 - 986GREAVES, DR论文数: 0 引用数: 0 h-index: 0WILSON, FD论文数: 0 引用数: 0 h-index: 0LANG, G论文数: 0 引用数: 0 h-index: 0KIOUSSIS, D论文数: 0 引用数: 0 h-index: 0
- [5] THE ANTIGEN-SPECIFIC, MAJOR HISTOCOMPATIBILITY COMPLEX-RESTRICTED RECEPTOR ON T-CELLS .6. AN ANTIBODY TO A RECEPTOR ALLOTYPE[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1984, 160 (02) : 452 - 471HASKINS, K论文数: 0 引用数: 0 h-index: 0机构: UNIV COLORADO,HLTH SCI CTR,DEPT BIOCHEM,DENVER,CO 80262HANNUM, C论文数: 0 引用数: 0 h-index: 0机构: UNIV COLORADO,HLTH SCI CTR,DEPT BIOCHEM,DENVER,CO 80262WHITE, J论文数: 0 引用数: 0 h-index: 0机构: UNIV COLORADO,HLTH SCI CTR,DEPT BIOCHEM,DENVER,CO 80262ROEHM, N论文数: 0 引用数: 0 h-index: 0机构: UNIV COLORADO,HLTH SCI CTR,DEPT BIOCHEM,DENVER,CO 80262KUBO, R论文数: 0 引用数: 0 h-index: 0机构: UNIV COLORADO,HLTH SCI CTR,DEPT BIOCHEM,DENVER,CO 80262KAPPLER, J论文数: 0 引用数: 0 h-index: 0机构: UNIV COLORADO,HLTH SCI CTR,DEPT BIOCHEM,DENVER,CO 80262MARRACK, P论文数: 0 引用数: 0 h-index: 0机构: UNIV COLORADO,HLTH SCI CTR,DEPT BIOCHEM,DENVER,CO 80262
- [6] AUTOIMMUNE DIABETES AS A CONSEQUENCE OF LOCALLY PRODUCED INTERLEUKIN-2[J]. NATURE, 1992, 359 (6395) : 547 - 549HEATH, WR论文数: 0 引用数: 0 h-index: 0机构: ROYAL MELBOURNE HOSP, WALTER & ELIZA HALL INST MED RES, PARKVILLE, VIC 3050, AUSTRALIAALLISON, J论文数: 0 引用数: 0 h-index: 0机构: ROYAL MELBOURNE HOSP, WALTER & ELIZA HALL INST MED RES, PARKVILLE, VIC 3050, AUSTRALIAHOFFMANN, MW论文数: 0 引用数: 0 h-index: 0机构: ROYAL MELBOURNE HOSP, WALTER & ELIZA HALL INST MED RES, PARKVILLE, VIC 3050, AUSTRALIASCHONRICH, G论文数: 0 引用数: 0 h-index: 0机构: ROYAL MELBOURNE HOSP, WALTER & ELIZA HALL INST MED RES, PARKVILLE, VIC 3050, AUSTRALIAHAMMERLING, G论文数: 0 引用数: 0 h-index: 0机构: ROYAL MELBOURNE HOSP, WALTER & ELIZA HALL INST MED RES, PARKVILLE, VIC 3050, AUSTRALIAARNOLD, B论文数: 0 引用数: 0 h-index: 0机构: ROYAL MELBOURNE HOSP, WALTER & ELIZA HALL INST MED RES, PARKVILLE, VIC 3050, AUSTRALIAMILLER, JFAP论文数: 0 引用数: 0 h-index: 0机构: ROYAL MELBOURNE HOSP, WALTER & ELIZA HALL INST MED RES, PARKVILLE, VIC 3050, AUSTRALIA
- [7] IMMUNE RECOGNITION - MLS - MAKES A LITTLE SENSE[J]. NATURE, 1991, 349 (6309) : 459 - 461JANEWAY, C论文数: 0 引用数: 0 h-index: 0
- [8] XENOGENEIC MONOCLONAL ANTIBODIES TO MOUSE LYMPHOID DIFFERENTIATION ANTIGENS[J]. IMMUNOLOGICAL REVIEWS, 1979, 47 : 63 - 90LEDBETTER, JA论文数: 0 引用数: 0 h-index: 0机构: Department of Genetics, Stanford University School of Medicine, Stanford, CaliforniaHERZENBERG, LA论文数: 0 引用数: 0 h-index: 0机构: Department of Genetics, Stanford University School of Medicine, Stanford, California
- [9] CD8 SURFACE LEVELS ALTER THE FATE OF ALPHA/BETA T-CELL RECEPTOR-EXPRESSING THYMOCYTES IN TRANSGENIC MICE[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (04) : 1013 - 1025LEE, NA论文数: 0 引用数: 0 h-index: 0机构: MEM SLOAN KETTERING CANC CTR,SLOAN KETTERING INST,PROGRAM MOLEC BIOL,DEWITT WALLACE RES LAB,NEW YORK,NY 10021LOH, DY论文数: 0 引用数: 0 h-index: 0机构: MEM SLOAN KETTERING CANC CTR,SLOAN KETTERING INST,PROGRAM MOLEC BIOL,DEWITT WALLACE RES LAB,NEW YORK,NY 10021LACY, E论文数: 0 引用数: 0 h-index: 0机构: MEM SLOAN KETTERING CANC CTR,SLOAN KETTERING INST,PROGRAM MOLEC BIOL,DEWITT WALLACE RES LAB,NEW YORK,NY 10021
- [10] IDENTIFICATION OF A MONOCLONAL-ANTIBODY SPECIFIC FOR A MURINE T3 POLYPEPTIDE[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (05) : 1374 - 1378LEO, O论文数: 0 引用数: 0 h-index: 0机构: NCI,IMMUNOL BRANCH,TRANSPLANTAT BIOL SECT,BETHESDA,MD 20892FOO, M论文数: 0 引用数: 0 h-index: 0机构: NCI,IMMUNOL BRANCH,TRANSPLANTAT BIOL SECT,BETHESDA,MD 20892SACHS, DH论文数: 0 引用数: 0 h-index: 0机构: NCI,IMMUNOL BRANCH,TRANSPLANTAT BIOL SECT,BETHESDA,MD 20892SAMELSON, LE论文数: 0 引用数: 0 h-index: 0机构: NCI,IMMUNOL BRANCH,TRANSPLANTAT BIOL SECT,BETHESDA,MD 20892BLUESTONE, JA论文数: 0 引用数: 0 h-index: 0机构: NCI,IMMUNOL BRANCH,TRANSPLANTAT BIOL SECT,BETHESDA,MD 20892