THE FIBER OF BOVINE ADENOVIRUS TYPE-3 IS VERY LONG BUT BENT

被引：23

作者：

RUIGROK, RWH

BARGE, A

MITTAL, SK

JACROT, B

机构：

[1] UNIV SASKATCHEWAN,VET INFECT DIS ORG,SASKATOON S7N 0W0,SK,CANADA

[2] ILL GRENOBLE,EUROPEAN MOLEC BIOL LAB,GRENOBLE OUTSTN,F-38042 GRENOBLE 9,FRANCE

来源：

JOURNAL OF GENERAL VIROLOGY | 1994年 / 75卷

关键词：

D O I：

10.1099/0022-1317-75-8-2069

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The sequence of the fibre of bovine adenovirus type 3 (BAd3) predicts an extremely long structure due to a large number of 15-residue repeats in the fibre shaft, the tail and head domains being similar in size to the human adenovirus fibres. The length of the fibre was confirmed using negative-strain electron microscopy of BAd3 pentons (fibre plus penton base). The fibre was found to be bent in several discrete places and the bending sites appear to correspond with irregular repeats in the shaft. We suggest that bending of the fibre is needed for the interaction of the penton base with the secondary receptors on the cell surface.

引用

页码：2069 / 2073

页数：5

共 13 条

[1] STRUCTURE OF ADENOVIRUS FIBER .1. ANALYSIS OF CRYSTALS OF FIBER FROM ADENOVIRUS SEROTYPE-2 AND SEROTYPE-5 BY ELECTRON-MICROSCOPY AND X-RAY CRYSTALLOGRAPHY [J].