A NEW FAMILY OF RETROVIRAL LONG TERMINAL REPEAT ELEMENTS IN THE HUMAN GENOME IDENTIFIED BY THEIR HOMOLOGIES TO AN ELEMENT 5' TO THE SPIDER MONKEY HAPTOGLOBIN GENE

被引:6
作者
ERICKSON, LM
MAEDA, N
机构
[1] UNIV N CAROLINA,CURRICULUM GENET,CHAPEL HILL,NC 27599
[2] UNIV N CAROLINA,DEPT PHYS,CHAPEL HILL,NC 27599
关键词
D O I
10.1006/geno.1995.1087
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A new family of retroviral long terminal repeats that we name Spm-LTR has been identified as a result of DNA sequence comparisons between the entire GenBank databank and an element, SPHP, located 5' to the haptoglobin gene of spider monkeys. The 18 human Spm-LTR sequences so identified fall into three subtypes. There is no sequence similarity between Spm-LTR elements and any endogenous retroviral LTR sequences previously reported except for general features that define LTRs. However, a previously described repeated sequence (MER-4) forms a portion of the Spm-LTR sequence. (C) 1995 Academic Press, Inc.
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页码:531 / 534
页数:4
相关论文
共 13 条
[1]  
Fields C.A., Grady D.L., Moyzis R.K., The human THE-LTR(O) and JVfsfll interspersed repeats are subfamilies of a single widely distributed highly variable repeat family, Genomics, 13, pp. 431-436, (1992)
[2]  
Goodchild N., Wilkinson D., Mager D., A human endogenous long terminal repeat polyadenylates a novel alternatively spliced transcript in normal placenta, Gene, 121, pp. 287-294, (1992)
[3]  
Jurka J., Novel families of interspersed repetitive elements from the human genome, Nucleic Acids Res, 18, pp. 137-141, (1990)
[4]  
Kaplan D.J., Jurka J., Solus J.F., Duncan C.H., Medium reiteration frequency repetitive sequences in the human genome, Nucleic Acids Res, 19, pp. 4731-4738, (1991)
[5]  
Keyeux G., Lefranc G., Lefranc M.-P., A multigene deletion in the human IGH constant region locus involves highly homologous hot spots of recombination, Genomics, 5, pp. 431-441, (1989)
[6]  
Krane D.E., Hardison R.C., Short interspersed repeats in rabbit DNA can provide functional polyadenylation signals, Mol. Biol. Evol., 7, pp. 1-8, (1990)
[7]  
Maeda N., Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair: The haptoglobin-related gene contains a retrovirus-like element, J. Biol. Chem, 260, pp. 6698-6709, (1985)
[8]  
Maeda N., Kim H.-S., Three independent insertions of retrovirus-like sequences in the haptoglobin gene cluster of primates, Genomics, 8, pp. 671-683, (1990)
[9]  
Perdue P.E., Lumb M.J., Fox M., Grififo G., Hamon-Benais C., Povey S., Danpure C.J., Characterization and chromosomal mapping of a genomic clone encoding human ala- nine.Glyoxylate aminotransferase, Genomics, 10, pp. 34-42, (1991)
[10]  
Smit A.F., Identification of a new, abundant superfamily of mammalian LTR-transposons, Nucleic Acids Res, 21, pp. 1863-1872, (1993)