CIRCADIAN RESPONSES TO LIGHT - THE CALMODULIN CONNECTION

被引：39

作者：

GOLOMBEK, DA ^{[1
]}

RALPH, MR ^{[1
]}

机构：

[1] UNIV TORONTO,DEPT PSYCHOL,TORONTO,ON M5S 1A1,CANADA

来源：

NEUROSCIENCE LETTERS | 1995年 / 192卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

CIRCADIAN RHYTHMS; PHASE SHIFTS; CAM KINASE II; KN-62; CALMODULIN; W-7; CREB;

D O I：

10.1016/0304-3940(95)99209-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

KN-62, an inhibitor of CaM kinase II, attenuated phase shifts induced by low intensity light pulses and reduced light-induced phosphorylation of the transcription factor, CREB, in the suprachiasmatic nucleus. The calmodulin inhibitor, W-7, had similar effects: neither drug produced a complete block of photic responses. The results support the hypothesis that circadian responses to light are mediated in part by CaM kinase activity and CREB, and suggest that other signal transduction pathways also take part.

引用

页码：101 / 104

页数：4

共 16 条

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