SYNTHESIS AND PROGESTATIONAL ACTIVITY OF SOME 1,2ALPHA-CYCLOMETHYLENE-16-METHYLENE PROGESTERONE DERIVATIVES

被引：16

作者：

SHAPIRO, EL

POPPER, TL

WEBER, L

NERI, R

HERZOG, HL

机构：

[1] Natural Products Research Department, Physiology and Biochemistry Department, Schering Corporation, Bloomfield

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 04期

关键词：

D O I：

10.1021/jm00304a016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The progestational activities and syntheses of the 1,2α-eyclomethylene-16-methylene compounds 4, 15, and 25 and of the precursor 1,4,6-trienes 26, 16, and 23 are reported. In all cases the trienes exhibited higher progestational activity than the corresponding 1,2α-cyclomethylene derivatives when tested intramuscularly in the rabbit. © 1969, American Chemical Society. All rights reserved.

引用

页码：631 / &

共 22 条

[1]

AFONSO A, PRIVATE COMMUNICATIO

[2]

BURN D, 1960, P CHEM SOC LONDON, P14

[3] DIMETHYLOXOSULFONIUM METHYLIDE ((CH3)2SOCH2) AND DIMETHYLSULFONIUM METHYLIDE ((CH3)2SCH2) FORMATION AND APPLICATION TO ORGANIC SYNTHESIS [J].

COREY, EJ ;

CHAYKOVSKY, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1965, 87 (06) :1353-+

[4]

DRYDEN HL, 1966, Patent No. 3270008

[5]

HUANGMINLON CH, 1962, SCI SINICA PEKING, V11, P1659

[6] MODIFIED STEROID HORMONES .22. 6ALPHA,16ALPHA-DIMETHYL-PROGESTERONE AND 17ALPHA-ACETOXY-6ALPHA-METHYL-16-METHYLENEPROGESTERONE [J].

KIRK, DN ;

WILLIAMSON, DM ;

PETROW, V .

JOURNAL OF THE CHEMICAL SOCIETY, 1961, (JUL) :2821-&

[7] MODIFIED STEROID HORMONES .16. 17-ALPHA-ACETOXY-16-METHYLENEPREGN-4-ENE-3,20-DIONE [J].

KIRK, DN ;

PETROW, V ;

STANSFIELD, M ;

WILLIAMSON, DM .

JOURNAL OF THE CHEMICAL SOCIETY, 1960, (JUN) :2385-2388

[8]

KIRK DN, 1962, Patent No. 899804

[9] SYNTHESIS OF STEROIDAL CYCLOPROPANO KETONES [J].

KRAKOWER, GW ;

VANDINE, HA .

JOURNAL OF ORGANIC CHEMISTRY, 1966, 31 (11) :3467-&

[10] A NEW SYNTHESIS OF BUTENOLIDES [J].

LEHMANN, HG .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1965, 4 (09) :783-&

← 1 2 3 →