POLYMORPHONUCLEAR LEUKOCYTE MOTILITY IN VITRO .2. STIMULATORY EFFECT OF MONOSODIUM URATE CRYSTALS AND URATE IN SOLUTION - PARTIAL INHIBITION BY COLCHICINE AND INDOMETHACIN

被引：41

作者：

PHELPS, P

机构：

[1] University of Pennsylvania, Philadelphia, Pennsylvania

[2] General Clinical Research Center, Philadelphia General Hospital, Philadelphia, Pennsylvania, 19104, Building 25

来源：

ARTHRITIS AND RHEUMATISM | 1969年 / 12卷 / 03期

关键词：

D O I：

10.1002/art.1780120305

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Studies were performed to determine the effect of monosodium urate crystals on motility of polymorphonuclear leukocytes (PMN's) in vitro, using a modification of the Boyden chamber technic. A stimulatory effect on the random motility of PMN's (not chemotaxis) was demonstrated which could be explained entirely on the basis of the urate in solution and could be blocked by uricase, colchicine, and indomethacin. Copyright © 1969 American College of Rheumatology

引用

页码：189 / &

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