SCHISTOSOMA-MANSONI - EFFECTS OF ANTIMONY ON IMMATURE AND ADULT WORMS

被引：7

作者：

COLES, GC ^{[1
]}

CHAPPELL, LH ^{[1
]}

机构：

[1] UNIV ABERDEEN,DEPT ZOOL,ABERDEEN AB9 1FX,SCOTLAND

来源：

EXPERIMENTAL PARASITOLOGY | 1979年 / 47卷 / 01期

基金：

英国惠康基金;

关键词：

EC; 2.7.1.11; Hexose phosphates; Mode of action; Phosphofructokinase; Potassium antimony tartrate; Schistosoma mansoni; Trematode;

D O I：

10.1016/0014-4894(79)90006-7

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Immature Schistosoma mansoni in mice are less susceptible to antimony therapy than adult worms. KSb tartrate inhibited phosphofructokinase (PFK) (EC 2.7.1.11) to a greater extent in extracts of 3-week-old worms than adults, and inhibited production of lactate in both immature and adult worms in vitro. In vivo, KSb tartrate was accumulated similarly by 3-week-old worms and by adults: measurements of hexosephosphate following drug treatment suggested similar inhibition of PFK in the two worm stages. If antimony acts by inhibition of PFK it is not clear why the young worms are more resistant to chemotherapy than adults. © 1979.

引用

页码：49 / 53

页数：5

共 19 条

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[10] SCHISTOSOMA-MANSONI - DEVELOPMENT OF VITELLINE CELL, ITS ROLE IN DRUG SEQUESTRATION, AND CHANGES INDUCED BY ASTIBAN
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