ENERGETICS OF PEPTIDE-BOND FORMATION AT ELEVATED-TEMPERATURES

被引:19
作者
FLEGMANN, AW
TATTERSALL, R
机构
[1] School of Biological Sciences, The University of Bath, Claverton Down, Bath
关键词
Free energy barrier to amino acid condensation; Prebiotic peptide bond formation;
D O I
10.1007/BF01732029
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The free energies of formation of the peptide bond between carbobenzoxy-glycine and L-phenylalanine amide in aqueous solution at temperatures up to 60°C were calculated from experimentally determined equilibrium constants. The reaction was catalyzed by a thermophylic enzyme. The thermodynamic energy barrier to peptide bond formation was found to decrease with increasing temperature: the standard free energy of peptide bond formation did appear to become negative in the region of 60°C. The possible significance of these results for peptide bond formation under prebiotic conditions is discussed. © 1979 Springer-Verlag.
引用
收藏
页码:349 / 355
页数:7
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