METABOLIC ACTIVATION OF AFLATOXINS RELATED TO THEIR MUTAGENICITY

被引：58

作者：

GURTOO, HL ^{[1
]}

DAHMS, RP ^{[1
]}

PAIGEN, B ^{[1
]}

机构：

[1] NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,CTR DRUG,DEPT GRACE CTR,BUFFALO,NY 14263

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1978年 / 81卷 / 03期

关键词：

D O I：

10.1016/0006-291X(78)91445-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rat hepatic microsome-mediated DNA-binding and mutagenesis to Salmonella typhimurium strain Ta-100 by various aflatoxins and some mixed function oxygenase-mediated metabolites of aflatoxin B1 were studied. The data indicated a good correlation between the DNA-binding and mutagenesis; a requirement for the intact C2-C3 double bond in parent aflatoxins B1 and G1; and relative inactivity of aflatoxin B1 metabolites with an otherwise intact C2-C3 double bond. © 1978.

引用

页码：965 / 972

页数：8

共 30 条

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