EFFECTS OF LOCAL APPLICATION OF OTOTOXIC ANTIBIOTICS ON COCHLEAR POTENTIALS IN GUINEA-PIGS

被引：32

作者：

KONISHI, T

机构：

[1] National Institute of Environmental Health Sciences, Research Triangle Park, NC

来源：

ACTA OTO-LARYNGOLOGICA | 1979年 / 88卷 / 1-2期

关键词：

D O I：

10.3109/00016487909137138

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

The effects of neomycin, kanamycin and dihydrostreptomycin on the cochlear microphonic, the action potential of the auditory nerve and the endocochlear potential were studied in guinea pigs in which these drugs were locally administered by perfusion. These drugs suppressed the cochlear responses markedly when applied to the endolymph but were less effective when applied to the perilymph. The mechanisms of action of antibiotics on the hair cells of the organ of Corti are discussed. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：41 / 46

页数：6

共 18 条

[1]

BALOGH K, 1970, ANN OTOL ST LOUIS, V19, P641

[2] EFFECTS OF ETHACRYNIC-ACID UPON COCHLEAR ENDOLYMPH AND STRIA VASCULARIS - PRELIMINARY REPORT [J].

BOSHER, SK ;

SMITH, C ;

WARREN, RL .

ACTA OTO-LARYNGOLOGICA, 1973, 75 (2-3) :184-191

[3] TEMPERATURE COEFFICIENTS OF COCHLEAR POTENTIALS [J].

BUTLER, RA ;

KONISHI, T ;

FERNANDEZ, C .

AMERICAN JOURNAL OF PHYSIOLOGY, 1960, 199 (04) :688-692

[4]

DAVIS H, 1958, Laryngoscope, V68, P596

[5]

DUVALL A J, 1964, Acta Otolaryngol, V57, P581, DOI 10.3109/00016486409137120

[6] DIMENSIONS OF THE COCHLEA (GUINEA PIG) [J].

FERNANDEZ, C .

JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 1952, 24 (05) :519-523

[7]

Harada Y, 1967, Acta Otolaryngol, V64, P327, DOI 10.3109/00016486709139120

[8]

HAWKINS JE, 1964, ACTA OTOLARYNGOL STO, V188

[9]

ILBERG CV, 1971, ACTA OTO-LARYNGOL, V71, P159

[10]

KOHONEN A, 1965, ACTA OTOLARYNGOL STO, V208

← 1 2 →