AMINOHALOBORANE IN ORGANIC-SYNTHESIS .2. SIMPLE SYNTHESIS OF INDOLES AND 1-ACYL-3-INDOLINONES USING SPECIFIC ORTHO-ALPHA-CHLOROACETYLATION OF ANILINES

被引：114

作者：

SUGASAWA, T

ADACHI, M

SASAKURA, K

KITAGAWA, A

机构：

[1] Shionogi Research Laboratory, Shionogi & Co., Ltd., Osaka 553, Fukushima-ku

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 04期

关键词：

D O I：

10.1021/jo01318a021

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general simple synthesis of 2, 3-unsubstituted indoles (5) and 1-acyl-3-indolinones (9 and 10) was performed from anilines in two steps. The general procedure involved (a) specific ortho chloroacetylation of anilines to give 2-amino-a-chloroacetophenones (4), and (b) reductive cyclization of 4 to produce 5 and dehydrochlorination of 2-(acylamino)-&-chloroacetophenones (7 and 8) to yield 9 and 10. © 1979, American Chemical Society. All rights reserved.

引用

页码：578 / 586

页数：9

共 23 条

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