REVERSAL OF AGE-RELATED COGNITIVE IMPAIRMENTS BY AN M1 CHOLINERGIC AGONIST, AF102B

被引：69

作者：

BRANDEIS, R ^{[1
]}

DACHIR, S ^{[1
]}

SAPIR, M ^{[1
]}

LEVY, A ^{[1
]}

FISHER, A ^{[1
]}

机构：

[1] ISRAEL INST BIOL RES,DEPT ORGAN CHEM,IL-70450 NESS ZIONA,ISRAEL

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1990年 / 36卷 / 01期

关键词：

AF102B; Aging; M1; agonist; Morris water maze; Radial arm maze;

D O I：

10.1016/0091-3057(90)90131-Z

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

This study examined the effect of a specific M1 cholinergic agonist, AF102B, on place learning of aged and young rats. Spatial reference memory was tested in the Morris Water Maze task, while spatial working memory was tested on an 8-arm radial maze. Both memory functions were impaired in aged rats compared to young animals. However, the administration of AF102B significantly reduced the age-related cognitive impairments observed in both tasks. This data supports the assertion of the "cholinergic hypothesis," namely that specific enhancement of cholinergic function may reverse geriatric cognitive deficits. © 1990.

引用

页码：89 / 95

页数：7

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