EVIDENCE FOR POLYMORPHONUCLEAR LEUKOCYTE COLLAGENASE AND 92-KILODALTON GELATINASE IN GINGIVAL CREVICULAR FLUID

被引：56

作者：

OVERALL, CM

SODEK, J

MCCULLOCH, CAG

BIREK, P

机构：

[1] UNIV TORONTO,MRC,PERIODONTOL PHYSIOL GRP,TORONTO M5S 1A1,ONTARIO,CANADA

[2] UNIV TORONTO,FAC DENT,TORONTO M5S 1A1,ONTARIO,CANADA

来源：

INFECTION AND IMMUNITY | 1991年 / 59卷 / 12期

关键词：

D O I：

10.1128/IAI.59.12.4687-4692.1991

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Analysis of inflammatory exudate collected from sites of experimental periodontitis in cynomolgus monkeys has revealed the presence of collagenase and a 92-kDa gelatinase that comigrated after electrophoresis with the 92-kDa gelatinase released from polymorphonuclear leukocytes. Since neutralizing antibodies to fibroblast collagenase had no effect on the collagenase activity and bacterial collagenases could not be detected, polymorphonuclear leukocytes appear to be the major source of collagenolytic proteinases in inflammatory fluid from gingiva.

引用

页码：4687 / 4692

页数：6

共 51 条

[1] ALEXANDER JW, 1968, J LAB CLIN MED, V72, P136
[2] MEASUREMENTS OF PROBING VELOCITY WITH AN AUTOMATED PERIODONTAL PROBE AND THE RELATIONSHIP WITH EXPERIMENTAL PERIODONTITIS IN THE CYNOMOLGUS MONKEY (MACACA-FASCICULARIS)
BIREK, P
MCCULLOCH, CAG
OVERALL, CM
[J]. ARCHIVES OF ORAL BIOLOGY, 1989, 34 (10) : 793 - 801
[3] MONOCLONAL-ANTIBODIES TO HUMAN FIBROBLAST PROCOLLAGENASE - INHIBITION OF ENZYMATIC-ACTIVITY, AFFINITY PURIFICATION OF THE ENZYME, AND EVIDENCE FOR CLUSTERING OF EPITOPES IN THE NH2-TERMINAL END OF THE ACTIVATED ENZYME
BIRKEDALHANSEN, B
MOORE, WGI
TAYLOR, RE
BHOWN, AS
BIRKEDALHANSEN, H
[J]. BIOCHEMISTRY, 1988, 27 (18) : 6751 - 6758
[4] DETERGENT-ACTIVATION OF LATENT COLLAGENASE AND RESOLUTION OF ITS COMPONENT MOLECULES
BIRKEDALHANSEN, H
TAYLOR, RE
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1982, 107 (04) : 1173 - 1178
[5] CHARACTERIZATION OF COLLAGENOLYTIC ACTIVITY FROM STRAINS OF BACTEROIDES-GINGIVALIS
BIRKEDALHANSEN, H
TAYLOR, RE
ZAMBON, JJ
BARWA, PK
NEIDERS, ME
[J]. JOURNAL OF PERIODONTAL RESEARCH, 1988, 23 (04) : 258 - 264
[6] CAMPBELL EJ, 1987, J BIOL CHEM, V262, P15862
[7] COLLIER IE, 1988, J BIOL CHEM, V263, P6579
[8] FERRANTEE A, 1978, J IMMUNOL METHODS, V4, P389
[9] IDENTIFICATION OF POLYMORPHONUCLEAR LEUKOCYTE COLLAGENASE AND GELATINASE ACTIVITIES IN MOUTHRINSE SAMPLES - CORRELATION WITH PERIODONTAL-DISEASE ACTIVITY IN ADULT AND JUVENILE PERIODONTITIS
GANGBAR, S
OVERALL, CM
MCCULLOCH, CAG
SODEK, J
[J]. JOURNAL OF PERIODONTAL RESEARCH, 1990, 25 (05) : 257 - 267
[10] COLLAGENOLYTIC ACTIVITY OF CREVICULAR FLUID FROM PERICORONAL GINGIVAL FLAPS
GOLUB, LM
KENNETT, S
MCEWAN, H
CURRAN, JB
RAMAMURTHY, NS
[J]. JOURNAL OF DENTAL RESEARCH, 1976, 55 (02) : 177 - 181

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