LIPOSOMAL AMPHOTERICIN-B IN DRUG-RESISTANT VISCERAL LEISHMANIASIS

被引:152
作者
DAVIDSON, RN [1 ]
CROFT, SL [1 ]
SCOTT, A [1 ]
MAINI, M [1 ]
MOODY, AH [1 ]
BRYCESON, ADM [1 ]
机构
[1] UNIV LONDON LONDON SCH HYG & TROP MED,LONDON WC1E 7HT,ENGLAND
关键词
D O I
10.1016/0140-6736(91)91708-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The treatment of visceral leishmaniasis (VL) may be complicated by drug toxicity or intolerance, and by drug resistance. 1 Amphotericin B (AmB) is effective, 1 but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common. Liposomes have been proposed as an effective way to target drugs at macrophages, which are the cells infected in visceral leishmaniasis. 2-7 In animals AmB incorporated into liposomes is highly effective against experimental leishmaniasis, with low toxicity. This report is of the successful treatment of a patient with multiply drug-resistant visceral leishmaniasis with a commercially prepared formulation of liposomal amphotericin B (L-AmB) ('AmBisome', Vestar, San Dimas, California, USA). We also report, for comparison, a patient treated with conventional AmB, and preliminary studies in mice comparing the two agents.
引用
收藏
页码:1061 / 1062
页数:2
相关论文
共 10 条
  • [1] ALVING C R, 1986, Parasitology Today, V2, P101, DOI 10.1016/0169-4758(86)90039-6
  • [2] THERAPY OF LEISHMANIASIS - SUPERIOR EFFICACIES OF LIPOSOME-ENCAPSULATED DRUGS
    ALVING, CR
    STECK, EA
    CHAPMAN, WL
    WAITS, VB
    HENDRICKS, LD
    SWARTZ, GM
    HANSON, WL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (06) : 2959 - 2963
  • [3] ANTILEISHMANIAL ACTIVITY OF LIPOSOME-ENCAPSULATED AMPHOTERICIN-B IN HAMSTERS AND MONKEYS
    BERMAN, JD
    HANSON, WL
    CHAPMAN, WL
    ALVING, CR
    LOPEZBERESTEIN, G
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (06) : 847 - 851
  • [4] BRYCESON ADM, 1987, THERAPY MAN, pCH18
  • [5] CHULAY JD, 1983, AM J TROP MED HYG, V32, P475, DOI 10.4269/ajtmh.1983.32.475
  • [6] Croft S. L., 1989, Leishmaniasis: The current status and new strategies for control. Proceedings of a NATO Advanced Study Institute on leishmaniasis: The first centenary (1885-1985), new strategies for control, Zakinthos, Greece, 20-27 September 1987., P783
  • [7] CROFT SL, 1986, PHARM INT, V7, P229
  • [8] LIPOSOMES AS CARRIERS OF ANTIMICROBIAL AGENTS
    LOPEZBERESTEIN, G
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (05) : 675 - 678
  • [9] ANTILEISHMANIAL ACTIVITY OF AMPHOTERICIN AND OTHER ANTIFUNGAL AGENTS ENTRAPPED IN LIPOSOMES
    NEW, RRC
    CHANCE, ML
    HEATH, S
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1981, 8 (05) : 371 - 381
  • [10] ANTILEISHMANIAL ACTIVITY OF ANTIMONIALS ENTRAPPED IN LIPOSOMES
    NEW, RRC
    CHANCE, ML
    THOMAS, SC
    PETERS, W
    [J]. NATURE, 1978, 272 (5648) : 55 - 56