INVITRO MODEL FOR THE DEGRADATION OF ALKYLCYANOACRYLATE NANOPARTICLES

被引：98

作者：

MULLER, RH ^{[1
]}

LHERM, C ^{[1
]}

HERBORT, J ^{[1
]}

COUVREUR, P ^{[1
]}

机构：

[1] UNIV PARIS 11,PHARM GALEN & BIOPHARM LAB,5 RUE JB CLEMENT,F-92290 CHATENAY MALABRY,FRANCE

来源：

BIOMATERIALS | 1990年 / 11卷 / 08期

关键词：

Biodegradation; drug delivery; nanoparticles;

D O I：

10.1016/0142-9612(90)90084-4

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A photometric assay was developed to study the surface erosion of polymeric nanoparticles. The hydrolytic degradation of polyalkylcyanoacrylate particles was studied in different environments (NaOH, buffer, cell culture medium and serum). The influence of particle modification on the degradation rate was assessed. Particularly, the effect of polymer coating for particle targeting and fluorescence labelling was investigated. From the absorption data, a t 50% and t 100% can be calculated for fast degrading particles and obtained by an extrapolation in case of a slow degradation process. The degradation rate was found to decrease with increasing alkyl chain length from methyl-, ethyl-, isobutyl- to isohexylcyanoacrylate particles. Polymer coating and fluorescent labelling had little effect on the rate of degradation. © 1990.

引用

页码：590 / 595

页数：6

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