LYSOPHOSPHATIDYLCHOLINE AS A POSSIBLE 2ND MESSENGER SYNERGISTIC TO DIACYLGLYCEROL AND CALCIUM-ION FOR LYMPHOCYTE-T ACTIVATION

被引：45

作者：

ASAOKA, Y ^{[1
]}

OKA, M ^{[1
]}

YOSHIDA, K ^{[1
]}

NISHIZUKA, Y ^{[1
]}

机构：

[1] KOBE UNIV,SCH MED,DEPT BIOCHEM,KOBE 650,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 178卷 / 03期

关键词：

D O I：

10.1016/0006-291X(91)91046-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An immediate reaction product of phosphatidylcholine hydrolysis catalyzed by phospholipase A2, lysophosphatidylcholine (lysoPC), synergizes with a membrane-permeable diacylglycerol, 1,2-dioctanoylglycerol, and ionomycin to activate resting T-lymphocytes as measured by interleukin-2 α-receptor expression. It is suggestive that both phospholipase C and phospholipase A2 are directly involved in signal transduction in a synergistic fashion and that lysoPC acts as an additional second messenger for cellular regulation, probably for long-term responses such as cell proliferation and differentiation. © 1991.

引用

页码：1378 / 1385

页数：8

共 19 条

[1] RECEPTOR-MEDIATED ACTIVATION OF PHOSPHOLIPASE-A2 VIA GTP-BINDING PROTEINS - ARACHIDONIC-ACID AND ITS METABOLITES AS 2ND MESSENGERS
AXELROD, J
BURCH, RM
JELSEMA, CL
[J]. TRENDS IN NEUROSCIENCES, 1988, 11 (03) : 117 - 123
[2] INOSITOL TRISPHOSPHATE, A NOVEL 2ND MESSENGER IN CELLULAR SIGNAL TRANSDUCTION
BERRIDGE, MJ
IRVINE, RF
[J]. NATURE, 1984, 312 (5992) : 315 - 321
[3] PROTEIN KINASE-C AND T-CELL ACTIVATION
BERRY, N
NISHIZUKA, Y
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1990, 189 (02): : 205 - 214
[4] ACTIVATION OF RESTING HUMAN T-CELLS REQUIRES PROLONGED STIMULATION OF PROTEIN KINASE-C
BERRY, N
ASE, K
KISHIMOTO, A
NISHIZUKA, Y
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (06) : 2294 - 2298
[5] BERRY N, 1989, J IMMUNOL, V143, P1407
[6] THE REGULATION AND CELLULAR FUNCTIONS OF PHOSPHATIDYLCHOLINE HYDROLYSIS
BILLAH, MM
ANTHES, JC
[J]. BIOCHEMICAL JOURNAL, 1990, 269 (02) : 281 - 291
[7] BJORNDAHL J, 1987, CLIN RES, V35, pA606
[8] EXTON JH, 1990, J BIOL CHEM, V265, P1
[9] KANOH H, 1983, J BIOL CHEM, V258, P1767
[10] PROPERTIES OF MICROSOMAL AND SOLUBLE DIACYLGLYCEROL KINASE IN RAT-LIVER
KANOH, H
AKESSON, B
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1978, 85 (01): : 225 - 232

← 1 2 →