EXPERIMENTAL DRUG-TREATMENT OF SCRAPIE - A PATHOGENETIC BASIS FOR RATIONALE THERAPEUTICS

被引：11

作者：

POCCHIARI, M

SALVATORE, M

LADOGANA, A

INGROSSO, L

XI, YG

CIBATI, M

MASULLO, C

机构：

[1] Department of Biology, University of Lecce, Lecce

[2] Institute of General Pathology, Catholic University, Rome

[3] Institute of Neurology, Catholic University, Rome

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 1991年 / 7卷 / 05期

关键词：

SCRAPIE; CREUTZFELDT-JAKOB DISEASE; THERAPY; AMPHOTERICIN-B; SULFATE POLYANIONS; PATHOGENESIS;

D O I：

10.1007/BF00143139

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Pharmacological treatment with polyanions or amphotericin B in hamsters with experimental scrapie reveals that it is possible to delay the appearance of the disease only when the drug is given before the invasion of the agent into the clinical target areas of the brain. We suggest such early treatment may be possible for individuals at high risk of acquiring the disease, such as healthy mutation-positive relatives of patients with familial Creutzfeldt-Jakob disease or Gerstmann-Straussler syndrome, or recipients of potentially contaminated pituitary-extracted human growth hormone.

引用

页码：556 / 561

页数：6

共 36 条

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