SIGNIFICANCE OF CHROMOSOMAL-ABNORMALITIES IN A MALIGNANT GIANT-CELL TUMOR OF BONE

被引：13

作者：

BRIDGE, JA

MOURON, BJ

NEFF, JR

BHATIA, PS

机构：

[1] UNIV KANSAS, MED CTR, DEPT PATHOL & ONCOL, KANSAS CITY, KS 66103 USA

[2] UNIV NEBRASKA, MED CTR, DEPT PEDIAT, OMAHA, NE 68198 USA

[3] UNIV NEBRASKA, MED CTR, DEPT ORTHOPAED SURG, OMAHA, NE 68198 USA

来源：

CANCER GENETICS AND CYTOGENETICS | 1991年 / 57卷 / 01期

关键词：

D O I：

10.1016/0165-4608(91)90193-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetic analysis of a malignant giant cell tumor of the sacrum from a 62-year-old female revealed the following chromosomal complement: 47,XX,-1,-11,+22,del(2)(p22),t(7;7) (p22;q32),+ der(1)t(1;11;21)(p32;q13;q22),+ der(19)t(19;?)(q13.4;?),der(8)t(8;?)(p11;?), der(7)t(17;?)(p13;?). Metaphase cells with 92-127 chromosomes sharing identical structural abnormalities detected in the near-diploid cells were also observed. Several of these abnormalities have previously been described in the benign giant cell tumors supporting a direct relationship between these benign and malignant neoplastic counterparts.

引用

页码：87 / 92

页数：6

共 32 条

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