CHEMOTHERAPEUTIC TREATMENTS INVOLVING DRUG-RESISTANCE AND LEVEL OF NORMAL-CELLS AS A CRITERION OF TOXICITY

被引：24

作者：

COSTA, MIS ^{[1
]}

BOLDRINI, JL ^{[1
]}

BASSANEZI, RC ^{[1
]}

机构：

[1] UNIV ESTADUAL CAMPINAS,INST MATEMAT ESTATIST & CIENCIA COMP,BR-13081970 CAMPINAS,BRAZIL

来源：

MATHEMATICAL BIOSCIENCES | 1995年 / 125卷 / 02期

关键词：

D O I：

10.1016/0025-5564(94)00028-X

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A system of differential equations for the control of tumor cells growth in a cycle nonspecific chemotherapy is presented. Drug resistance and toxicity conveyed through the level of normal cells are taken into account in a class of optimal control problems. Alternative treatments for the exponential tumor growth are set forth for cases where optimal treatments are not available.

引用

页码：211 / 228

页数：18

共 24 条

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