BIOCATALYTIC PREPARATION OF CHIRAL ALCOHOLS BY ENANTIOSELECTIVE REDUCTION WITH IMMOBILIZED CELLS OF CARROT

被引：34

作者：

AKAKABE, Y

TAKAHASHI, M

KAMEZAWA, M

KIKUCHI, K

TACHIBANA, H

OHTANI, T

NAOSHIMA, Y

机构：

[1] OKAYAMA UNIV SCI,FAC SCI,DEPT BIOCHEM,OKAYAMA 700,JAPAN

[2] KONAN CHEM IND CO LTD,TAKATSUKI,OSAKA 569,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 10期

关键词：

D O I：

10.1039/p19950001295

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The ability of immobilized cells of Daucus cal ota to reduce enantioselectively organic foreign substrates has been examined. The immobilized plant cells reduced, with excellent enantioselectivity, prochiral ketone substrates such as keto esters, aromatic ketones and heterocyclic aromatic ketones, leading to the corresponding chiral secondary alcohols with an enantiomeric purity of 52-99% ee in a chemical yield of 30-63%.

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页码：1295 / 1298

页数：4

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