STATUS EPILEPTICUS DURING VIGABATRIN TREATMENT - A REPORT OF 3 CASES

被引：15

作者：

DEKROM, MCTFM

VERDUIN, N

VISSER, E

KLEIJER, M

SCHOLTES, F

DEGROEN, JHM

机构：

[1] UNIV LIMBURG HOSP,DEPT NEUROL,6202 AZ MAASTRICHT,NETHERLANDS

[2] UNIV LIMBURG HOSP,DEPT CLIN NEUROPHYSIOL,6202 AZ MAASTRICHT,NETHERLANDS

[3] DR HANS BERGER KLINIEK,BREDA,NETHERLANDS

来源：

SEIZURE | 1995年 / 4卷 / 02期

关键词：

STATUS EPILEPITUS; VIGABATRIN;

D O I：

10.1016/S1059-1311(95)80099-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Vigabatrin (gamma-vinyl-GABA or GVG) is an irreversible inhibitor of gamma-aminobutyric acid transaminase (GABA-T), which is an enzyme responsible for gamma-aminobutyric acid (GABA) catabolism. Inhibition of GABA catabolism increases brain concentration of GABA, a neural inhibitor. GVG has been found to be a potent new anti-epileptic drug, especially in the treatment of refractory epilepsy, in particular of complex partial seizures. Three patients who developed a severe status epilepitcus while on GVG treatment are reported. A possible proconvulsive effect of GVG is hypothesized, which might result from disinhibition in the nigro-collicular pathway due to increased GABA-levels,

引用

页码：159 / 162

页数：4

共 18 条

[1]

Gale, GABA in epilepsy: the pharmacologic basis, Epilepsia, 30, pp. SI-S11, (1989)

[2]

Gibson, Yarrington, Loudy, Gerbig, Hurst, Newberne, Chronic toxicity studies with vigabatrin, a GABA-transaminase inhibitor, Toxicologic Pathology, 18, pp. 225-238, (1990)

[3]

Ring, Heller, Farr, Reynolds, Vigabatrin: rational treatment for chronic epilepsy, Journal of Neurology, Neurosurgery and Psychiatry (London), 53, 12, pp. 1051-1055, (1990)

[4]

Mumford, Dulac, Vigabatrin: a new antiepileptic medication, Journal of Child Neurology, 6, pp. 2S3-2S6, (1991)

[5]

Dulac, Chiron, Et al., Vigabatrin in childhood epilepsy, Journal of Child Neurology, 6, pp. 2530-2537, (1991)

[6]

Reynolds, Phenytoin toxicity, Antiepileptic Drugs, pp. 241-255, (1989)

[7]

Prior, Maclaine, Scott, Laurance, Tonic status epilepticus precipitated by intravenous diazepam in a child with petit mal status, Epilepsia, 13, pp. 467-472, (1972)

[8]

Tassinari, Dravet, Roger, Cano, Gastaut, Tonic status epilepticus precipitated by intravenous benzodiazepine in five patients with Lennox-Gastaut syndrome, Epilepsia, 13, pp. 421-435, (1972)

[9]

Horn, Ater, Hurst, Carbamazepineexacerbated epilepsy in children and adolescents, Pediatric Neurology, 2, pp. 340-345, (1986)

[10]

Snead, Hosey, Exacerbation of seizures in children by carbamazepine, New England Journal of Medicine, 313, pp. 916-921, (1985)

← 1 2 →