MOLECULAR-CLONING OF 25-HYDROXYVITAMIN-D-3 24-HYDROXYLASE (CYP-24) FROM MOUSE KIDNEY - ITS INDUCIBILITY BY VITAMIN-D-3

被引：23

作者：

ITOH, S

YOSHIMURA, T

IEMURA, O

YAMADA, E

TSUJIKAWA, K

KOHAMA, Y

MIMURA, T

机构：

[1] Division of Bio-Medical and Immunological Chemistry, Faculty of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565, 1-6, Yamadaoka

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1995年 / 1264卷 / 01期

关键词：

CDNA CLONING; CYP24; CYTOCHROME-P-450; 1-ALPHA; 25-DIHYDROXYVITAMIN-D-3; VITAMIN-D-3;

D O I：

10.1016/0167-4781(95)00147-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cDNA encoding a 25-hydroxyvitamin D-3 24-hydroxylase, Cyp-24. has been isolated from mouse kidney cDNA library by hybridization screening. Mouse Cyp-24, coding for 514 amino acid residues. shared 82.1 and 94.7% amino acid identity with human and rat CYP24s, respectively. Among mouse organs examined, Cyp-24 mRNA could be detected in the kidney. When mice were treated with vitamin D-3, Cyp-24 mRNA was induced in the kidney.

引用

页码：26 / 28

页数：3

共 12 条

[1] ISOLATION AND EXPRESSION OF HUMAN 1,25-DIHYDROXYVITAMIN-D3 24-HYDROXYLASE CDNA
CHEN, KS
PRAHL, JM
DELUCA, HF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (10) : 4543 - 4547
[2] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE
CHIRGWIN, JM
PRZYBYLA, AE
MACDONALD, RJ
RUTTER, WJ
[J]. BIOCHEMISTRY, 1979, 18 (24) : 5294 - 5299
[3] VITAMIN-D - RECENT ADVANCES
DELUCA, HF
SCHNOES, HK
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1983, 52 : 411 - 439
[4] TARGETING PROTEINS INTO MITOCHONDRIA
DOUGLAS, MG
MCCAMMON, MT
VASSAROTTI, A
[J]. MICROBIOLOGICAL REVIEWS, 1986, 50 (02) : 166 - 178
[5] IDENTIFICATION OF A VITAMIN-D RESPONSIVE ELEMENT IN THE PROMOTER OF THE RAT CYTOCHROME P450(24) GENE
HAHN, CN
KERRY, DM
OMDAHL, JL
MAY, BK
[J]. NUCLEIC ACIDS RESEARCH, 1994, 22 (12) : 2410 - 2416
[6] THE P450 SUPERFAMILY - UPDATE ON NEW SEQUENCES, GENE-MAPPING, ACCESSION NUMBERS, EARLY TRIVIAL NAMES OF ENZYMES, AND NOMENCLATURE
NELSON, DR
KAMATAKI, T
WAXMAN, DJ
GUENGERICH, FP
ESTABROOK, RW
FEYEREISEN, R
GONZALEZ, FJ
COON, MJ
GUNSALUS, IC
GOTOH, O
OKUDA, K
NEBERT, DW
[J]. DNA AND CELL BIOLOGY, 1993, 12 (01) : 1 - 51
[7] STRUCTURAL CHARACTERIZATION OF THE GENE ENCODING RAT 25-HYDROXYVITAMIN-D(3) 24-HYDROXYLASE
OHYAMA, Y
NOSHIRO, M
EGGERTSEN, G
GOTOH, O
KATO, Y
BJORKHEM, I
OKUDA, K
[J]. BIOCHEMISTRY, 1993, 32 (01) : 76 - 82
[8] OHYAMA Y, 1994, J BIOL CHEM, V269, P10545
[9] CLONING AND EXPRESSION OF CDNA-ENCODING 25-HYDROXYVITAMIN-D3 24-HYDROXYLASE
OHYAMA, Y
NOSHIRO, M
OKUDA, K
[J]. FEBS LETTERS, 1991, 278 (02) : 195 - 198
[10] SHINKI T, 1992, J BIOL CHEM, V267, P13757

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