DETERMINATION OF BROMHEXINE AS ITS TRIFLUOROACETYL DERIVATIVE BY GAS-LIQUID-CHROMATOGRAPHY WITH ELECTRON-CAPTURE DETECTION

被引：12

作者：

DELEENHEER, AP

VANDECASTEELETHIENPONT, LMR

机构：

[1] Laboratoria voor Medische Biochemie en voor Klinische Analyse, Faculteit van de Farmaceutische Wetenschappen, Akademisch Ziekenhuis, B-9000 Gent

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 175卷 / 02期

关键词：

D O I：

10.1016/S0021-9673(00)89436-4

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A specific gas-liquid chromatographie method with electron-capture detection is described for the determination of bromhexine at the nanogram level. Structurally analogous internal standards were synthesized and their suitability was investigated, based on their chromatographic properties on different stationary liquid phases. The electron-capture activity of the compounds is increased by trifluoroacetylation. Reaction conditions for this derivatization were studied. Calibration graphs in the range 0-57 ng (in a total of 100 μl of reaction mixture) showed good linearity. © 1979.

引用

页码：301 / 306

页数：6

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