DIFFERENTIAL SENSITIVITIES OF GLIOMA-CELLS AND NEURO-BLASTOMA CELLS TO METHYLMERCURY TOXICITY IN CULTURES

被引：38

作者：

PRASAD, KN

NOBLES, E

RAMANUJAM, M

机构：

[1] Department of Radiology, University of Colorado Medical Center, Denver

来源：

ENVIRONMENTAL RESEARCH | 1979年 / 19卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0013-9351(79)90046-X

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The effects of mercury compounds in rat glioma (C-6) and mouse neuroblastoma (NBP2) cells in culture were studied. Glioma cells were more sensitive to methylmercuric chloride (CH3HgCl) than neuroblastoma (NB) cells for the criterion of growth inhibition (due to cell death and inhibition of cell division). This may be due in part to the fact that glioma cells accumulated more CH3203HgCl than NB cells. The biological half-life of CH3203HgCl in glioma cells was less (3.2-5.2 hr) than that in NB cells (7 - 7.3 hr). Although a much higher concentration of mercuric chloride (HgCl2) was required to produce effects similar to those produced by CH3HgCl, it produced no differential effects on glioma and NB cells. © 1979.

引用

页码：189 / 201

页数：13

共 20 条

[1] METABOLISM OF METHYL MERCURY (203HG) COMPOUNDS IN MAN - EXCRETION AND DISTRIBUTION [J].