THE EFFECT OF CIAMEXONE ON LYMPHOCYTIC THYROIDITIS AND INSULIN-DEPENDENT DIABETES-MELLITUS IN THE BB/WOR RAT

被引：1

作者：

ABEND, S

CORMIER, J

APPEL, MC

LUEPRASITSAKUL, W

ALEX, S

MORDES, JP

USADEL, KH

HANDLER, ES

ROSSINI, AA

BRAVERMAN, LE

机构：

[1] UNIV HEIDELBERG, KLINIKUM MANNHEIM, MED KLIN 2, W-6800 MANNHEIM 1, GERMANY

[2] UNIV MASSACHUSETTS, SCH MED, DEPT PATHOL, WORCESTER, MA 01655 USA

[3] UNIV MASSACHUSETTS, SCH MED, DEPT MED, WORCESTER, MA 01655 USA

来源：

IMMUNOPHARMACOLOGY | 1990年 / 19卷 / 03期

关键词：

BB rat; Ciamexone; IDDM; Lymphocytic thyroiditis;

D O I：

10.1016/0162-3109(90)90065-M

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Previous studies have suggested that ciamexone, a 2-cyan-aziridine derivative, is a selective immunomodulatory agent with potential therapeutic application in a variety of autoimmune diseases. In the present study, the effects of ciamexone on autoimmune lymphocytic thyroiditis and diabetes mellitus were studied in the BB rat. The data suggest that, in this animal model, ciamexone does not affect the frequency of autoimmune diabetes or lymphocytic thyroiditis nor does it affect the serum TSH or T4 concentrations. © 1990.

引用

页码：163 / 168

页数：6

共 30 条

[1] IODINE-INDUCED THYROIDITIS AND HYPOTHYROIDISM IN THE HEMITHYROIDECTOMIZED BB/W RAT [J].