A MATHEMATICAL-MODEL OF THE KINETICS OF PLATELETS AND PLASMA HEMOSTASIS SYSTEM INTERACTION

被引：12

作者：

KHANIN, MA ^{[1
]}

LEYTIN, VL ^{[1
]}

POPOV, AP ^{[1
]}

机构：

[1] ACAD SCI USSR,CTR CARDIOL,INST EXPTL CARDIOL,MOSCOW V-71,USSR

来源：

THROMBOSIS RESEARCH | 1991年 / 64卷 / 06期

关键词：

HEMOCOAGULATION; PLATELETS; KINETICS; MATHEMATICAL MODEL; FEEDBACK;

D O I：

10.1016/0049-3848(91)90066-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A mathematical model of the kinetics of platelet-activated blood coagulation is presented. Non-linear positive feedbacks due to the action of co-factor Va and VIIIa, thrombin-induced platelet activation, the secretion of factor V by platelets are taken into account. The intrinsic pathway is shown not to be activated in the absence of platelets for small stimulation intensities. The activation occurs if initial platelet activation by inductors other than thrombin exceeds a threshold value.

引用

页码：659 / 666

页数：8

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