INVIVO INHIBITION OF TONB-DEPENDENT PROCESSES BY A TONB BOX CONSENSUS PENTAPEPTIDE

被引：50

作者：

TUCKMAN, M ^{[1
]}

OSBURNE, MS ^{[1
]}

机构：

[1] AMER CYANAMID CO,LEDERLE LABS,DEPT MICROBIAL GENET & BIOCHEM,PEARL RIVER,NY 10965

来源：

JOURNAL OF BACTERIOLOGY | 1992年 / 174卷 / 01期

关键词：

D O I：

10.1128/jb.174.1.320-323.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The TonB box, a conserved pentapeptide sequence found in TonB-dependent colicins and receptors, is thought to interact physically with the TonB protein to facilitate TonB-dependent processes. Strains of Escherichia coli were treated in vivo with the synthetic TonB box pentapeptide Glu-Thr-Val-Ile-Val. The pentapeptide inhibited several TonB-dependent processes, including cell growth in low-iron medium, phi-80 infection, and killing by colicins B and Ia. Two unrelated control pentapeptides had no effect on TonB-dependent processes.

引用

页码：320 / 323

页数：4

共 20 条

[1] PENETRATION OF COLICIN-M INTO CELLS OF ESCHERICHIA-COLI [J].

BRAUN, V ;

FRENZ, J ;

HANTKE, K ;

SCHALLER, K .

JOURNAL OF BACTERIOLOGY, 1980, 142 (01) :162-168

[2] STRUCTURE AND FUNCTION OF X-PRO DIPEPTIDE REPEATS IN THE TONB PROTEINS OF SALMONELLA-TYPHIMURIUM AND ESCHERICHIA-COLI [J].

BREWER, S ;

TOLLEY, M ;

TRAYER, IP ;

BARR, GC ;

DORMAN, CJ ;

HANNAVY, K ;

HIGGINS, CF ;

EVANS, JS ;

LEVINE, BA ;

WORMALD, MR .

JOURNAL OF MOLECULAR BIOLOGY, 1990, 216 (04) :883-895

[3] A SIMPLIFIED RAPID METHOD FOR THE REMOVAL OF IRON AND OTHER CATIONS FROM COMPLEX MEDIA [J].

DOMINGUE, PAG ;

MOTTLE, B ;

MORCK, DW ;

BROWN, MRW ;

COSTERTON, JW .

JOURNAL OF MICROBIOLOGICAL METHODS, 1990, 12 (01) :13-22

[4] POINT MUTATIONS IN A CONSERVED REGION (TONB BOX) OF ESCHERICHIA-COLI OUTER-MEMBRANE PROTEIN BTUB AFFECT VITAMIN-B12 TRANSPORT [J].

GUDMUNDSDOTTIR, A ;

BELL, PE ;

LUNDRIGAN, MD ;

BRADBEER, C ;

KADNER, RJ .

JOURNAL OF BACTERIOLOGY, 1989, 171 (12) :6526-6533

[5] FUNCTIONAL INTERACTION OF TONA-TONB RECEPTOR SYSTEM IN ESCHERICHIA-COLI [J].

HANTKE, K ;

BRAUN, V .

JOURNAL OF BACTERIOLOGY, 1978, 135 (01) :190-197

[6] MEMBRANE RECEPTOR DEPENDENT IRON TRANSPORT IN ESCHERICHIA-COLI [J].

HANTKE, K ;

BRAUN, V .

FEBS LETTERS, 1975, 49 (03) :301-305

[7] INDUCTION OF COLICIN FACTOR E2-P9 BY MITOMYCIN-C [J].

HARDY, KG ;

MEYNELL, GG .

JOURNAL OF BACTERIOLOGY, 1972, 112 (02) :1007-&

[8] SUPPRESSION OF THE BTUB451 MUTATION BY MUTATIONS IN THE TONB GENE SUGGESTS A DIRECT INTERACTION BETWEEN TONB AND TONB-DEPENDENT RECEPTOR PROTEINS IN THE OUTER-MEMBRANE OF ESCHERICHIA-COLI [J].

HELLER, KJ ;

KADNER, RJ ;

GUNTHER, K .

GENE, 1988, 64 (01) :147-153

[9] GENETIC ORGANIZATION OF THE OLIGOPEPTIDE PERMEASE (OPP) LOCUS OF SALMONELLA-TYPHIMURIUM AND ESCHERICHIA-COLI [J].

HOGARTH, BG ;

HIGGINS, CF .

JOURNAL OF BACTERIOLOGY, 1983, 153 (03) :1548-1551

[10] INVITRO COMPETITION BETWEEN FERRICHROME AND PHAGE FOR OUTER MEMBRANE T5 RECEPTOR COMPLEX OF ESCHERICHIA-COLI [J].

LUCKEY, M ;

WAYNE, R ;

NEILANDS, JB .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1975, 64 (02) :687-693

← 1 2 →