EXTRACELLULAR DNA LEVEL IN THE BLOOD OF IRRADIATED RATS

被引：11

作者：

VLADIMIROV, VG ^{[1
]}

BELOKHVOSTOV, AS ^{[1
]}

SHERLINA, SS ^{[1
]}

VASILYEVA, IN ^{[1
]}

VOSKRESENSKY, AM ^{[1
]}

机构：

[1] USSR DEF MINIST,MIL MED RES INST,ST PETERSBURG,RUSSIA

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1992年 / 62卷 / 06期

关键词：

D O I：

10.1080/09553009214552611

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

There is high-molecular DNA in the blood of unirradiated rats which moves as a single fraction during electrophoresis in 0.5% agarose. At short times (2-5 h) after gamma-irradiation at doses from 1 to 100 Gy a low-molecular species of DNA appears (about 180 nucleotide pairs), the amount of which is directly proportional to exposure dose at 5 h after exposure. It has been established by Southern hybridization that the low-molecular DNA has few nucleotide sequences common with those of the high-molecular DNA, but it shows homologously to genomic sequences.

引用

页码：667 / 671

页数：5

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